Evidence map›Paper›PMID 21234775›Full record

GuidelineNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2011

Natalizumab therapy of multiple sclerosis: recommendations of the Multiple Sclerosis Study Group--Italian Neurological Society.

A Ghezzi, L M E Grimaldi, M G Marrosu, C Pozzilli, G Comi, A Bertolotto, M Trojano, P Gallo, R Capra, D Centonze and 17 more

Abstract readPractice Guideline
PubMed Publisher
In one paragraph

Guideline in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 19 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. The use of natalizumab for multiple sclerosis.Neuropsychiatric disease and treatment · 2017
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 17 institutions in 1 country.

A GhezziU.O. Neurologia II, Centro Studi Sclerosi Multipla, Ospedale di Gallarate, Gallarate, Italy. angelo.ghezzi@aogallarate.it
L M E Grimaldi
M G Marrosu
C Pozzilli
G Comi
A Bertolotto
M Trojano
P Gallo
R Capra
D Centonze
E Millefiorini
S Sotgiu
V Brescia Morra
M P Amato
A Lugaresi
G Mancardi
D Caputo
E Montanari
L Provinciali
L Durelli
R Bergamaschi
P Bellantonio
M R Tola
S Cottone
G Savettieri
G Tedeschi
MS-SIN Study Group
Istituto Neurologico Mediterraneo · ITMarche Polytechnic University · ITOspedale Vincenzo Cervello · ITUniversity of Cagliari · ITUniversity of Chieti-Pescara · ITUniversity of Padua · ITUniversity of Rome Tor Vergata · ITUniversity of Sassari · ITAssociazione Italiana Sclerosi Multipla · ITAzienda Ospedaliera Sant'Andrea · ITDon Carlo Gnocchi Foundation · ITFondazione Istituto Neurologico Nazionale Casimiro Mondino · ITIRCCS Ospedale San Raffaele · ITOspedale San Luigi Gonzaga · ITUniversity of Florence · ITUniversity of Palermo · ITUniversity of Parma · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Three years after the introduction of natalizumab (NA) therapy for the second line treatment of relapsing-remitting multiple sclerosis (MS), Italian MS centers critically reviewed the scientific literature and their own clinical experience. Natalizumab was shown to be highly efficacious in the treatment of MS. However, the risk of progressive multifocal leukoencephalopathy was confirmed and defined better. This article summarizes the MS-SIN Study Group recommendations on the use of NA in MS, with particular reference to the appropriate selection and monitoring of patients as well as to the management of adverse events.

Indexed as

Antibodies, MonoclonalAntibodies, Monoclonal, HumanizedHumansLeukoencephalopathy, Progressive MultifocalMultiple Sclerosis, Relapsing-RemittingNatalizumabAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedNatalizumab

Identifiers

PMID21234775
OpenAlexW1995019460

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.