Evidence map›Paper›PMID 21234730›Full record

ReviewCurrent rheumatology reports2011

The immune system, the skin, and childhood rheumatic disease.

Robert C Fuhlbrigge, Rafka Chaiban

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current rheumatology reports, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Robert C FuhlbriggeProgram in Rheumatology, Division of Immunology, Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA. robert.fuhlbrigge@childrens.harvard.edu
Rafka Chaiban
Boston Children's Hospital · USChildren's Hospital · TN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As the body's largest organ and first line of defense against the environment, the skin plays a vital role in host immune defense. In addition to its function as a physical barrier, the skin contains an active immune surveillance network and can mount highly specific responses to eliminate invading organisms. In this review, we discuss the functions of adhesion molecules in regulating the recruitment of distinct cell populations to skin in both healthy and disease states, and the interaction between innate and adaptive immune mechanisms active in the skin. We also review how these systems underlie the pathogenesis of skin manifestations of pediatric rheumatologic diseases.

Indexed as

AdolescentB-LymphocytesCell MovementChildHumansImmune SystemImmunologic SurveillanceLangerhans CellsRheumatic DiseasesSkinT-Lymphocytes

Identifiers

PMID21234730
OpenAlexW2035227262

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.