ReviewPharmaceutical research2011
Effects of surfactants on lipase structure, activity, and inhibition.
Review in Pharmaceutical research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 172 citations in OpenAlex.
- Infant milk fat droplet size and coating affect postprandial responses in healthy adult men: a proof-of-concept study.European journal of clinical nutrition · 2017Trial
- In Vitro Evidence of α-Linolenic Acid Ethyl Ester Hydrolysis and Transesterification in the Gastrointestinal Tract in the Presence of Acylglycerols.Journal of agricultural and food chemistry · 2026Article
- Assessment of the interaction between sodium dodecyl sulfate and trypsin enzyme through micellization and thermodynamic analysis.RSC advances · 2026Article
- Synthetic pancreatic lipase inhibitors in obesity treatment: current updates onRSC medicinal chemistry · 2025Review
- Versatile biocatalyst: lipase fromFrontiers in bioengineering and biotechnology · 2025Article
- Article
- A Novel Lipase fromInternational journal of molecular sciences · 2023Article
- Article
- Oil-Based Delivery Control Release System Targeted to the Later Part of the Gastrointestinal Tract-A Mechanistic Study.Pharmaceutics · 2022Article
- Algicidal characteristics of novel algicidal compounds, cyclic lipopeptide surfactins fromFrontiers in microbiology · 2022Article
- Article
- High-efficiency expression of the thermophilic lipase from3 Biotech · 2020Article
- Strong inhibitory activities and action modes of lipopeptides on lipase.Journal of enzyme inhibition and medicinal chemistry · 2020Article
- Biochemical characterization of an esterase from Clostridium acetobutylicum with novel GYSMG pentapeptide motif at the catalytic domain.Journal of industrial microbiology & biotechnology · 2020Article
- Identification and Characterization of a Novel Hyperthermostable Bifunctional Cellobiohydrolase- Xylanase Enzyme for Synergistic Effect With Commercial Cellulase on Pretreated Wheat Straw Degradation.Frontiers in bioengineering and biotechnology · 2020Article
- Enhanced digestion inhibition and mucus penetration of F127-modified self-nanoemulsions for improved oral delivery.Asian journal of pharmaceutical sciences · 2018Article
- Lipids in the Stomach - Implications for the Evaluation of Food Effects on Oral Drug Absorption.Pharmaceutical research · 2018Review
- Characterization of ML-005, a Novel Metaproteomics-Derived Esterase.Frontiers in microbiology · 2018Article
- Pharmacokinetic aspects and in vitro-in vivo correlation potential for lipid-based formulations.Acta pharmaceutica Sinica. B · 2014Review
- A new cold-adapted, organic solvent stable lipase from mesophilic Staphylococcus epidermidis AT2.The protein journal · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lipase inhibitors are the main anti-obesity drugs prescribed these days, but the complexity of their mechanism of action is making it difficult to develop new molecules for this purpose. The efficacy of these drugs is known to depend closely on the physico-chemistry of the lipid-water interfaces involved and on the unconventional behavior of the lipases which are their target enzymes. The lipolysis reaction which occurs at an oil-water interface involves complex equilibria between adsorption-desorption processes, conformational changes and catalytic mechanisms. In this context, surfactants can induce significant changes in the partitioning of the enzyme and the inhibitor between the water phase and lipid-water interfaces. Surfactants can be found at the oil-water interface where they compete with lipases for adsorption, but also in solution in the form of micellar aggregates and monomers that may interact with hydrophobic parts of lipases in solution. These various interactions, combined with the emulsification and dispersion of insoluble substrates and inhibitors, can either promote or decrease the activity and the inhibition of lipases. Here, we review some examples of the various effects of surfactants on lipase structure, activity and inhibition, which show how complex the various equilibria involved in the lipolysis reaction tend to be.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.