Evidence map›Paper›PMID 21234657›Full record

ArticlePharmaceutical research2011

Nano-fibrous tissue engineering scaffolds capable of growth factor delivery.

Jiang Hu, Peter X Ma

Abstract read
In one paragraph

Article in Pharmaceutical research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Controlled drug release for tissue engineering.Journal of controlled release : official journal of the Controlled Release Society · 2015
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jiang HuDepartment of Biologic and Materials Sciences, The University of Michigan, 1011 North University Ave, Room 2211, Ann Arbor, Michigan 48109-1078, USA.
Peter X Ma

Funding

Periodontal Engineering Using Biomimetic Nano ScaffoldsR01DE015384 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MA, PETER X · 2003 to 2011
$2.9M
Orchestrating Bone Regeneration on Multiple ScalesR01DE017689 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MA, PETER X · 2007 to 2010
$1.4M
Nano Fibers for ADME/ToxicologyR21GM075840 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MA, PETER X · 2006 to 2008
$931k
Biomimetic Nano ScaffoldsR21DE014755 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MA, PETER X · 2003 to 2004
$306k
NIDCR NIH HHS DE014755NIDCR NIH HHS DE015384NIDCR NIH HHS DE017689NIDCR NIH HHS R01 DE015384NIDCR NIH HHS R01 DE017689NIDCR NIH HHS R21 DE014755NIGMS NIH HHS GM075840NIGMS NIH HHS R21 GM075840
6 · The paper itself

Abstract

Tissue engineering aims at constructing biological substitutes to repair damaged tissues. Three-dimensional (3D) porous scaffolds are commonly utilized to define the 3D geometry of tissue engineering constructs and provide adequate pore space and surface to support cell attachment, migration, proliferation, differentiation and neo tissue genesis. Biomimetic 3D scaffolds provide synthetic microenvironments that mimic the natural regeneration microenvironments and promote tissue regeneration process. While nano-fibrous (NF) scaffolds are constructed to mimic the architecture of NF extracellular matrix, controlled-release growth factors are incorporated to modulate the regeneration process. The present article summarizes current advances in methods to fabricate NF polymer scaffolds and the technologies to incorporate controlled growth factor delivery systems into 3D scaffolds, followed by examples of accelerated regeneration when the scaffolds with growth factor releasing capacity are applied in animal models.

Indexed as

Tissue ScaffoldsAnimalsDelayed-Action PreparationsDrug Delivery SystemsHumansIntercellular Signaling Peptides and ProteinsNanofibersPolymersTissue EngineeringDelayed-Action PreparationsIntercellular Signaling Peptides and ProteinsPolymers

Identifiers

PMID21234657
PMCPMC3100424

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.