ArticleJournal of bone and mineral metabolism2011
Ultrasound bone mass in patients undergoing chronic therapy with oral anticoagulants.
Article in Journal of bone and mineral metabolism, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.
- A Systematic Review and Meta-analysis of the Association Between Vitamin K Antagonist Use and Fracture.Journal of general internal medicine · 2019Pooled it
- Direct oral anticoagulants and the risk of osteoporotic fractures in patients with non-valvular atrial fibrillation.Therapeutic advances in musculoskeletal disease · 2021Article
- Association of Anticoagulant Therapy With Risk of Fracture Among Patients With Atrial Fibrillation.JAMA internal medicine · 2020Article
- Alcohol Consumption and Bone Mineral Density in People with HIV and Substance Use Disorder: A Prospective Cohort Study.Alcoholism, clinical and experimental research · 2018Article
- Periodontal and biochemical bone metabolism assessment on a chronic oral anticoagulation population treated with dicoumarins.Medicina oral, patologia oral y cirugia bucal · 2017Article
- Warfarin use and fracture risk: an evidence-based mechanistic insight.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2015Article
- Association between the stress fracture and bone metabolism/quality markers in lacrosse players.Open access journal of sports medicine · 2012Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The purpose of this study was to assess the effects of chronic oral anticoagulant (OAC) treatment on bone mass using quantitative ultrasound (QUS) techniques. A total of 120 patients (47 women and 73 men) undergoing treatment with OAC and 57 healthy subjects (27 women and 30 men) participated in this study. Bone status was assessed using QUS devices that measure the amplitude-dependent speed of sound (Ad-SoS) in phalanges and the broadband ultrasound attenuation (BUA) in the calcaneus. Men undergoing OAC treatment had lower Ad-SoS, Z-score, T-score, and BUA values (all p < 0.005) and higher levels of undercarboxylated osteocalcin (u-OC) and tartrate-resistant acid phosphatase (TRAP) (both p < 0.0001) than controls. Women receiving OAC treatment had lower BUA values (p < 0.005) and total osteocalcin (OC) levels (p < 0.0001) and higher levels of u-OC and TRAP (both p < 0.0001) than controls. There was a statistically significant negative correlation between u-OC levels and Ad-SoS values in both men (r = -0.432, p = 0.0328) and women (r = -0.332, p = 0.0269) undergoing OAC treatment. In conclusion, patients undergoing OAC treatment had a loss of trabecular and cortical bone mass, possibly due to a decrease in the γ-carboxylation of osteocalcin resulting from the vitamin K antagonism of these drugs.
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Registered trials
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