ArticleInternational journal of legal medicine2011
Age and gender-dependent bone density changes of the human skull disclosed by high-resolution flat-panel computed tomography.
Article in International journal of legal medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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12 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
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- Micro-CT analysis reveals the changes in bone mineral density in zebrafish craniofacial skeleton with age.Journal of anatomy · 2023Article
- Investigating Tau and Amyloid Tracer Skull Binding in Studies of Alzheimer Disease.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023Article
- Estimation of sex using morphometric measurements performed on cranial computerized tomography scans.La Radiologia medica · 2021Article
- Transcranial Direct Current Stimulation at 4 mA Induces Greater Leg Muscle Fatigability in Women Compared to Men.Brain sciences · 2020Article
- Imaging Transcranial Direct Current Stimulation (tDCS) with Positron Emission Tomography (PET).Brain sciences · 2020Review
- How far can the radiation dose be lowered in head CT with iterative reconstruction? Analysis of imaging quality and diagnostic accuracy.European radiology · 2013Article
- Sex difference in tDCS current mediated by changes in cortical anatomy: A study across young, middle and older adults.Brain stimulationArticle
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe objective of this article was to estimate the age at death in forensic or anthropologic applications based on human skull investigation. Sex-dependent differences were analyzed.
methodsDigital, high-resolution, flat-panel-based volumetric computed tomography (eXplore Locus Ultra scanner) images (165,920) of 244 European human skulls-163 males, 81 females-were analyzed according to their radiological bone density, based on Hounsfield units (H) that are directly related to the x-ray attenuation of the scanned material. Data were collected by the Department of Forensic Medicine at the University Hospital Giessen and Marburg during 2007 and 2008. Correlation analysis was used for data description.
resultsHuman skull density estimates are widely scattered as a function of age for both sexes. Male skull bone density remains constant during lifetime, whereas female skull bone density decays slowly from approximately 20 years onwards.
conclusionsBone density decay only theoretically provides a new method to determine age at death for adult females. Due to the scattering of the data, an accuracy of approximately ±18 years is found at a confidence interval of 75%, which is, unfortunately, of limited practical interest. We found new sex differences of bone density decay in the skull that are potentially of relevance for the general understanding of bone degradation processes.
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