ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2011
Radiation-induced tumors in children irradiated for brain tumor: a longitudinal study.
Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 6 of them syntheses that pooled it.
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Who cites it
48 citing papers in PubMed, 6 syntheses or guidelines pooled it, 84 citations in OpenAlex.
- Radiation-induced cavernoma in pediatric CNS tumors: a systematic review and treatment paradigm.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Pooled it
- The Japan Society for Neuro-Oncology guideline on the diagnosis and treatment of central nervous system germ cell tumors.Neuro-oncology · 2022Guideline
- Natural history and treatment options of radiation-induced brain cavernomas: a systematic review.Neurosurgical review · 2022Pooled it
- Risk of secondary malignant neoplasms in children following proton therapy vs. photon therapy for primary CNS tumors: A systematic review and meta-analysis.Frontiers in oncology · 2022Pooled it
- Pooled it
- Subsequent neoplasms of the CNS among survivors of childhood cancer: a systematic review.The Lancet. Oncology · 2013Pooled it
- Radiation-induced meningiomas: A systematic review and meta-analysis of 927 meningiomas.Surgical neurology international · 2026Review
- Focused ultrasound-microbubble treatment arrests the growth and formation of cerebral cavernous malformations.Nature biomedical engineering · 2025Article
- Malignant Transformation of Meningiomas.Journal of Cancer · 2025Review
- Case report: A second case of cerebral cavernous malformation after high-dose chemotherapy for medulloblastoma.Frontiers in oncology · 2024Article
- Distinct patterns of copy number alterations may predict poor outcome in central nervous system germ cell tumors.Scientific reports · 2023Article
- [Secondary tumors following radiation therapy and chemotherapy : Incidence of cavernous hemangiomas].Radiologie (Heidelberg, Germany) · 2023Review
- Multiple meningiomas: Epidemiology, management, and outcomes.Neuro-oncology advances · 2023Article
- Radiation-induced meningiomas (RIM) in adults: A single-centre retrospective experience.Brain & spine · 2023Article
- Radiation-Induced Papillary Meningioma: A Case Report.Asian journal of neurosurgery · 2022Article
- Surveillance of long-term complications after treatment of adult brain tumor survivors-review and evidence-based recommendations.Neuro-oncology practice · 2022Review
- A Huge Radiation-Induced Cavernous Hemangioma Following Stereotactic Radiosurgery for Meningioma: A Case Report.Brain tumor research and treatment · 2022Article
- Biomarkers for risk-based treatment modifications for CNS germ cell tumors: Updates on biological underpinnings, clinical trials, and future directions.Frontiers in oncology · 2022Review
- Clinicopathological differences in radiation-induced organizing hematomas of the brain based on type of radiation treatment and primary lesions.Journal of pathology and translational medicine · 2022Article
- Glioblastoma Following Treated Medulloblastoma After 29 Years in the Posterior Fossa: Case Report and Review of Literature.Frontiers in oncology · 2022Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRadiation-induced tumors (RIT) are increasingly recognized as delayed complications of brain irradiation during childhood. However, the true incidence is not established, their biology is poorly understood, and few guidelines exist regarding the long-term follow-up of irradiated children.
methodsWe studied retrospectively patients irradiated for brain tumor under 18 years and followed in our institution since 1970. RIT were defined as new masses, different from the original tumor, occurring after delay in irradiated areas, and not related to phacomatosis.
resultsAmong 552 irradiated patients, 42 (7.6%) developed one or more RIT, 26 months to 29 years after irradiation (mean 12.8 years). The cumulated incidence was 2.0% at 5 years and 8.9% at 10 years. Of the patients, 73.8% were adult at the time of diagnosis of RIT, and 75% were diagnosed within 18.1 years after irradiation. We identified 60 cavernomas, 26 meningiomas, 2 malignant gliomas, 1 meningosarcoma, and 6 thyroid tumors. Compared with meningiomas, cavernomas appeared earlier, in children irradiated at an older age, and with a male predominance. Although RIT were correlated with higher irradiation doses, 80.9% of these occurred at some distance from the maximum irradiation field. Twenty-five lesions were operated in 20 patients; three patients died because of progression of the RIT.
conclusionA significant number of patients undergoing irradiation for brain tumor during childhood develop a RIT, often during adulthood. Our data suggest that radiation-induced cavernomas result from angiogenetic processes rather than true tumorigenesis. Protracted follow-up with MRI is warranted in children irradiated for brain tumor.
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