ArticleThe EMBO journal1990
Dissection of thymocyte signaling pathways by in vivo expression of pertussis toxin ADP-ribosyltransferase.
Article in The EMBO journal, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
79 citing papers in PubMed, 226 citations in OpenAlex.
- MAP4K3/GLK inhibits Treg differentiation by direct phosphorylating IKKβ and inducing IKKβ-mediated FoxO1 nuclear export and Foxp3 downregulation.Theranostics · 2022Article
- Induction of Interferon-γ and Tissue Inflammation by Overexpression of Eosinophil Cationic Protein in T Cells and Exosomes.Arthritis & rheumatology (Hoboken, N.J.) · 2022Article
- SRSF1 serves as a critical posttranscriptional regulator at the late stage of thymocyte development.Science advances · 2021Article
- BPI overexpression suppresses Treg differentiation and induces exosome-mediated inflammation in systemic lupus erythematosus.Theranostics · 2021Article
- Loss of GαScientific reports · 2017Article
- Extensive phenotypic characterization of a new transgenic mouse reveals pleiotropic perturbations in physiology due to mesenchymal hGH minigene expression.Scientific reports · 2017Article
- Expression of Twist2 is controlled by T-cell receptor signaling and determines the survival and death of thymocytes.Cell death and differentiation · 2016Article
- Protein kinase D regulates positive selection of CD4Nature communications · 2016Article
- TAGLN2 regulates T cell activation by stabilizing the actin cytoskeleton at the immunological synapse.The Journal of cell biology · 2015Article
- Autoimmunity-associated LYP-W620 does not impair thymic negative selection of autoreactive T cells.PloS one · 2014Article
- How to find your way through the thymus: a practical guide for aspiring T cells.Cellular and molecular life sciences : CMLS · 2012Review
- Targeted overexpression of an activated N-ras gene results in B-cell and plasma cell lymphoproliferation and cooperates with c-myc to induce fatal B-cell neoplasia.Experimental hematology · 2012Article
- Blockade of receptor-activated G(i) signaling in osteoblasts in vivo leads to site-specific increases in cortical and cancellous bone formation.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2011Article
- Differentiation of human T cells alters their repertoire of G protein alpha-subunits.The Journal of biological chemistry · 2010Article
- The TLX1 oncogene drives aneuploidy in T cell transformation.Nature medicine · 2010Article
- Altered thymic selection and increased autoimmunity caused by ectopic expression of DRAK2 during T cell development.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- Sonic hedgehog negatively regulates pre-TCR-induced differentiation by a Gli2-dependent mechanism.Blood · 2009Article
- Article
- Overexpression of lymphotoxin in T cells induces fulminant thymic involution.The American journal of pathology · 2008Article
- Probing cell type-specific functions of Gi in vivo identifies GPCR regulators of insulin secretion.The Journal of clinical investigation · 2007Article
19 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Stimulation of the T lymphocyte antigen receptor-CD3 complex (TCR-CD3) causes T cell activation by a process associated with increased phosphatidylinositol-specific phospholipase C (PI-PLC) activity. Evidence exists suggesting that GTP-binding (G) proteins, particularly the pertussis toxin (PT)-sensitive Gi proteins, participate in this signal transduction pathway. To clarify the role of Gi proteins in TCR-CD3 signaling, and to investigate other possible functions of Gi molecules in T cells, we expressed the S1 subunit of PT in the thymocytes of transgenic mice using the lymphocyte-specific lck promoter. Transgenic thymocytes contained S1 activity and exhibited profound depletion of Gi protein PT substrates in a manner suggesting their inactivation by S1 in vivo. Nevertheless, treatment of transgenic thymocytes with mitogenic stimuli provoked normal increases in intracellular free Ca2+ concentrations and IL-2 secretion, indicating that Gi proteins are not required for T cell activation. These normal signaling responses notwithstanding, mature thymocytes accumulated in lck-PT mice and did not appear in secondary lymphoid organs or in the circulation. Viewed in the context of the known features of Bordetella pertussis infection, our results suggest that a PT-sensitive signaling process, probably involving Gi proteins, regulates thymocyte emigration.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.