ArticleExperimental diabetes research2010
Fenofibrate treatment enhances antioxidant status and attenuates endothelial dysfunction in streptozotocin-induced diabetic rats.
Article in Experimental diabetes research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 58 citations in OpenAlex.
- Beneficial Effect of Fenofibrate in Combination with Silymarin on Parameters of Hereditary Hypertriglyceridemia-Induced Disorders in an Animal Model of Metabolic Syndrome.Biomedicines · 2025Article
- Sexual Dimorphism in Impairment of Acetylcholine-Mediated Vasorelaxation in Zucker Diabetic Fatty (ZDF) Rat Aorta: A Monogenic Model of Obesity-Induced Type 2 Diabetes.International journal of molecular sciences · 2024Article
- Review article: vascular effects of PPARs in the context of NASH.Alimentary pharmacology & therapeutics · 2022Review
- Protective Effect of Gemfibrozil on Hepatotoxicity Induced by Acetaminophen in Mice: the Importance of Oxidative Stress Suppression.Advanced pharmaceutical bulletin · 2018Article
- Fenofibrate exerts protective effects against gentamicin-induced toxicity in cochlear hair cells by activating antioxidant enzymes.International journal of molecular medicine · 2017Article
- Salusin-Oxidative medicine and cellular longevity · 2017Article
- Resveratrol and fenofibrate ameliorate fructose-induced nonalcoholic steatohepatitis by modulation of genes expression.World journal of gastroenterology · 2016Article
- Fibrates inhibit the apoptosis of Batten disease lymphoblast cells via autophagy recovery and regulation of mitochondrial membrane potential.In vitro cellular & developmental biology. Animal · 2016Article
- Modulation of Hypercholesterolemia-Induced Oxidative/Nitrative Stress in the Heart.Oxidative medicine and cellular longevity · 2016Review
- Gemfibrozil attenuates the inflammatory response and protects rats from abdominal sepsis.Experimental and therapeutic medicine · 2015Article
- Restoration of Endothelial Function in Pparα (-/-) Mice by Tempol.PPAR research · 2015Article
- Pharmacological protection of retinal pigmented epithelial cells by sulindac involves PPAR-α.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Peroxisome proliferator-activated receptor α protects capillary pericytes in the retina.The American journal of pathology · 2014Article
- Sexual dimorphism in rat aortic endothelial function of streptozotocin-induced diabetes: possible involvement of superoxide and nitric oxide production.European journal of pharmacology · 2014Article
- Peroxisome Proliferator Activator Receptor (PPAR)- γ Ligand, but Not PPAR- α , Ameliorates Cyclophosphamide-Induced Oxidative Stress and Inflammation in Rat Liver.PPAR research · 2014Article
- High FFA levels related to microalbuminuria and uncoupling of VEGF-NO axis in obese rats.International urology and nephrology · 2013Article
- Biological evaluation of a siliconized analog of clofibrate (silafibrate) in rodents.Iranian journal of pharmaceutical research : IJPR · 2013Article
- Endothelium-dependent Effect of Sesame Seed Feeding on Vascular Reactivity of Streptozotocin-diabetic Rats: Underlying Mechanisms.Iranian journal of pharmaceutical research : IJPR · 2013Article
- The case for intraocular delivery of PPAR agonists in the treatment of diabetic retinopathy.BMC ophthalmology · 2012Review
- Citrus flavonoid naringenin improves aortic reactivity in streptozotocin-diabetic rats.Indian journal of pharmacology · 2012Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diabetic endothelial dysfunction is accompanied by increased oxidative stress and upregulated proinflammatory and inflammatory mediators in the vasculature. Activation of peroxisome proliferator-activated receptor-alpha (PPAR-α) results in antioxidant and anti-inflammatory effects. This study was designed to investigate the effect of fenofibrate, a PPAR-α activator, on the endothelial dysfunction, oxidative stress, and inflammation in streptozotocin diabetic rats. Diabetic rats received fenofibrate (150 mg kg(-1) day(-1)) for 4 weeks. Fenofibrate treatment restored the impaired endothelium-dependent relaxation and increased basal nitric oxide availability in diabetic aorta, enhanced erythrocyte/liver superoxide dismutase and catalase levels, ameliorated the abnormal serum/aortic thiobarbituric acid reactive substances, and prevented the increased aortic myeloperoxidase without a significant change in serum total cholesterol and triglyceride levels. It did not affect the decreased total homocysteine level and the increased tumor necrosis factor-α level in the serum of diabetic rats. Fenofibrate-induced prevention of the endothelial function seems to be related to its potential antioxidant and antiinflammatory activity.
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