ArticleExperimental diabetes research2010
Creating a long-term diabetic rabbit model.
Article in Experimental diabetes research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 81 citations in OpenAlex.
- Synergistic antidiabetic efficacy of dorzolamide and metformin: HPTLC quantification and biological evaluation.Scientific reports · 2026Article
- Animal models in human surgery and implant innovation: ethical considerations and scientific advancements.Annals of medicine and surgery (2012) · 2025Article
- Assessment of the effects of hyperbaric oxygen treatment on new bone formation after sinus lift in a diabetic rabbit model.International journal of implant dentistry · 2025Article
- Comparative Analysis of Animal Models in Wound Healing Research and the Utility for Humanized Mice Models.Advances in wound care · 2025Review
- Innovative Strategies: Use of Stromal Cell-Derived Secretome for Chronic Wound Therapy.International journal of molecular sciences · 2025Review
- Creating an Extremely Long-lasting Neuroischemic Wound Model.JID innovations : skin science from molecules to population health · 2025Article
- Evaluation of the Accuracy of FreeStyle Libre 2 for Glucose Monitoring in White New Zealand Rabbits.Veterinary medicine and science · 2025Article
- A Fresh Look at Islet Isolation from Rabbit Pancreases.International journal of molecular sciences · 2024Article
- Effect of pomegranate peel with/without autologous bone marrow on healing of acute cutaneous wounds in alloxan-induced diabetic rabbits.Open veterinary journal · 2024Article
- The assessment of marrow adiposity in type 1 diabetic rabbits through magnetic resonance spectroscopy is linked to bone resorption.Frontiers in endocrinology · 2024Article
- Article
- Evaluation of a Rabbit Model of Vascular Stent Healing: Application of Optical Coherence Tomography.Journal of cardiovascular translational research · 2023Article
- Single-Dose Treatment with Rapamycin Preserves Post-Ischemic Cardiac Function through Attenuation of Fibrosis and Inflammation in Diabetic Rabbit.International journal of molecular sciences · 2023Article
- Chronic Wound Healing Models.ACS pharmacology & translational science · 2023Article
- Effects of ibuprofen-loaded TiO₂ nanotube dental implants in alloxan-induced diabetic rabbits.Journal of periodontal & implant science · 2021Article
- A novel surgical model for the preclinical assessment of the osseointegration of dental implants: a surgical protocol and pilot study results.Journal of translational medicine · 2021Article
- Cyclophilin A induces macrophage apoptosis and enhances atherosclerotic lesions in high-fat diet-fed hyperglycemic rabbits.FASEB bioAdvances · 2021Article
- Empagliflozin modulates renal sympathetic and heart rate baroreflexes in a rabbit model of diabetes.Diabetologia · 2020Article
- Efficacy of Bioactive Glass Nanofibers Tested for Oral Mucosal Regeneration in Rabbits with Induced Diabetes.Materials (Basel, Switzerland) · 2020Article
- Practical considerations for reducing mortality rates in alloxan-induced diabetic rabbits.Heliyon · 2020Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
This study was to create a long-term rabbit model of diabetes mellitus for medical studies of up to one year or longer and to evaluate the effects of chronic hyperglycemia on damage of major organs. A single dose of alloxan monohydrate (100 mg/kg) was given intravenously to 20 young New Zealand White rabbits. Another 12 age-matched normal rabbits were used as controls. Hyperglycemia developed within 48 hours after treatment with alloxan. Insulin was given daily after diabetes developed. All animals gained some body weight, but the gain was much less than the age-matched nondiabetic rabbits. Hyperlipidemia, higher blood urea nitrogen and creatinine were found in the diabetic animals. Histologically, the pancreas showed marked beta cell damage. The kidneys showed significantly thickened afferent glomerular arterioles with narrowed lumens along with glomerular atrophy. Lipid accumulation in the cytoplasm of hepatocytes appeared as vacuoles. Full-thickness skin wound healing was delayed. In summary, with careful management, alloxan-induced diabetic rabbits can be maintained for one year or longer in reasonably good health for diabetic studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.