ArticleJournal of biomedicine & biotechnology2011
Approaching biomarkers of membranous nephropathy from a murine model to human disease.
Article in Journal of biomedicine & biotechnology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 27 citations in OpenAlex.
- Therapeutic insights and molecular mechanism linking melatonin signaling and membranous nephropathy (Review).Biomedical reports · 2025Review
- Modeling SILAC Data to Assess Protein Turnover in a Cellular Model of Diabetic Nephropathy.International journal of molecular sciences · 2023Article
- Knockout of the neonatal Fc receptor alters immune complex trafficking and lysosomal function in cultured podocytes.PloS one · 2023Article
- Lysosome function in glomerular health and disease.Cell and tissue research · 2021Review
- Inhibition of tumor necrosis factor signaling attenuates renal immune cell infiltration in experimental membranous nephropathy.Oncotarget · 2017Article
- Cathepsin D protects renal tubular cells from damage induced by high glucose independent of its enzymatic activity.American journal of translational research · 2017Article
- ChIP-seq analysis of histone H3K9 trimethylation in peripheral blood mononuclear cells of membranous nephropathy patients.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2014Article
- A novel link: in children, cow milk processing may be causative of idiopathic membranous nephropathy.International urology and nephrology · 2012Review
- An overview of molecular mechanism of nephrotic syndrome.International journal of nephrology · 2012Article
- A pilot trial assessing urinary gene expression profiling with an mRNA array for diabetic nephropathy.PloS one · 2012Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMembranous glomerulonephropathy (MN) is the most prevalent cause of nephrotic syndrome in adult humans. However, the specific biomarkers of MN have not been fully elucidated. We examined the alterations in gene expression associated with the development of MN.
methodsMurine MN was induced by cationic bovine serum albumin (cBSA). After full-blown MN, cDNA microarray analysis was performed to identify gene expression changes, and highly expressed genes were evaluated as markers both in mice and human kidney samples.
resultsMN mice revealed clinical proteinuria and the characteristic diffuse thickening of the glomerular basement membrane. There were 175 genes with significantly different expressions in the MN kidneys compared with the normal kidneys. Four genes, metallothionein-1 (Mt1), cathepsin D (CtsD), lymphocyte 6 antigen complex (Ly6), and laminin receptor-1 (Lamr1), were chosen and quantified. Mt1 was detected mainly in tubules, Lamr1 was highly expressed in glomeruli, and CtsD was detected both in tubules and glomeruli. The high expressions of Lamr1 and CtsD were also confirmed in human kidney biopsies.
conclusionThe murine MN model resembled the clinical and pathological features of human MN and may provide a tool for investigating MN. Applying cDNA microarray analysis may help to identify biomarkers for human MN.
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