ArticleBreast cancer : basic and clinical research2010
Phytohemagglutinin-induced mitotic index in blood lymphocytes: a potential biomarker for breast cancer risk.
Article in Breast cancer : basic and clinical research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 9 citations in OpenAlex.
- Characterization of alpha-1-acid glycoprotein as a potential biomarker for breast cancer.Bioengineered · 2022Article
- Expression analysis of cytokines IL-5, IL-6, IL-8, IL-17 and VEGF in breast cancer patients.Frontiers in oncology · 2022Article
- Antioxidant and immune responses of broiler chickens supplemented withVeterinary world · 2021Article
- Trajectories of Stress, Depressive Symptoms, and Immunity in Cancer Survivors: Diagnosis to 5 Years.Clinical cancer research : an official journal of the American Association for Cancer Research · 2017Article
- Can consumption of raw vegetables decrease the count of sister chromatid exchange? Results from a cross-sectional study in Krakow, Poland.European journal of nutrition · 2015Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundCell proliferation is associated with the pathogenesis of cancer because it provides opportunities for accumulating genetic mutations. However, biomarkers of cell proliferation in response to environmental stimuli have not been adequately explored for breast cancer risk.
methodsIn a case-control study of 200 breast cancer patients and 360 healthy controls, we investigated the association between phytohemagglutinin (PHA)-induced mitotic index in blood lymphocyte and breast cancer risk.
resultsHaving high mitotic index (>3.19%) was associated with an increased risk of breast cancer, with adjusted odds ratios (95% confidence interval) of 1.54 (1.03-2.30) and 2.03 (1.18-3.57) for all women and post-menopausal women, respectively. Mitotic index was correlated with some reproductive factors and body mass index in controls.
conclusionsOur data suggest increased PHA-induced mitotic index in blood lymphocytes is associated with an increased breast cancer risk and that this association may be modulated by reproductive and other hormones.
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