ArticleInternational journal of medical sciences2011
Ozone therapy and hyperbaric oxygen treatment in lung injury in septic rats.
Article in International journal of medical sciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 51 citations in OpenAlex.
- Trial
- Experimental evidence for the beneficial effects of low-concentration ozone.Medical gas research · 2027Review
- Hyperbaric oxygen therapy in sepsis-associated encephalopathy: pathophysiological rationale, preclinical evidence, and translational challenges.Frontiers in cellular neuroscience · 2026Review
- Mucosal-adapted bacteriophages as a preventive strategy for a lethal Pseudomonas aeruginosa challenge in mice.Communications biology · 2025Article
- Low-Dose Ozone as a Eustress Inducer: Experimental Evidence of the Molecular Mechanisms Accounting for Its Therapeutic Action.International journal of molecular sciences · 2024Review
- Ozone therapy mitigates parthanatos after ischemic stroke.Biological research · 2024Article
- Evaluation of the Efficacy of Ozone Therapy on Liver Tissue in the Treatment of Sepsis in Rats with Cecal Perforation.Medicina (Kaunas, Lithuania) · 2024Article
- Ozonated triglyceride protects against septic lethality via preventing the activation of NLRP3 inflammasome.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2023Article
- Effects of ozone therapy on acidic corneal burns in rats.Veterinary research forum : an international quarterly journal · 2023Article
- Comparative treatment with hyperbaric oxygen therapy in a model of systemic loxoscelism in rats.Iranian journal of basic medical sciences · 2022Article
- Oxygen therapy for sepsis and prevention of complications.Acute and critical care · 2022Article
- Safety of inhaled ivermectin as a repurposed direct drug for treatment of COVID-19: A preclinical tolerance study.International immunopharmacology · 2021Article
- Protective effect of thymoquinone against lung intoxication induced by malathion inhalation.Scientific reports · 2021Article
- Immunomodulatory Effect of Colistin and its Protective Role in Rats with Methicillin-ResistantFrontiers in pharmacology · 2020Article
- Pulmonary effects of ozone therapy at different doses combined with antibioticotherapy in experimental sepsis model.Acta cirurgica brasileira · 2020Article
- Poly-ADP-ribose polymerase inhibition provides protection against lung injury in a rat paraquat toxicity model.Inflammopharmacology · 2016Article
- Ukrain (NSC 631570) ameliorates intestinal ischemia-reperfusion-induced acute lung injury by reducing oxidative stress.Bosnian journal of basic medical sciences · 2016Article
- Histopathological Study of Cyclosporine Pulmonary Toxicity in Rats.Journal of toxicology · 2016Article
- Hyperbaric oxygen treatment ameliorates lung injury in paraquat intoxicated rats.International journal of clinical and experimental pathology · 2015Article
- Saikosaponin-d attenuates ventilator-induced lung injury in rats.International journal of clinical and experimental medicine · 2015Article
Corrections and comments
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Authors and funding
17 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Various therapeutic protocols were used for the management of sepsis including hyperbaric oxygen (HBO) therapy. It has been shown that ozone therapy (OT) reduced inflammation in several entities and exhibits some similarity with HBO in regard to mechanisms of action. We designed a study to evaluate the efficacy of OT in an experimental rat model of sepsis to compare with HBO. Male Wistar rats were divided into sham, sepsis+cefepime, sepsis+cefepime+HBO, and sepsis+cefepime+OT groups. Sepsis was induced by an intraperitoneal injection of Escherichia coli; HBO was administered twice daily; OT was set as intraperitoneal injections once a day. The treatments were continued for 5 days after the induction of sepsis. At the end of experiment, the lung tissues and blood samples were harvested for biochemical and histological analysis. Myeloperoxidase activities and oxidative stress parameters, and serum proinflammatory cytokine levels, IL-1β and TNF-α, were found to be ameliorated by the adjuvant use of HBO and OT in the lung tissue when compared with the antibiotherapy only group. Histologic evaluation of the lung tissue samples confirmed the biochemical outcome. Our data presented that both HBO and OT reduced inflammation and injury in the septic rats' lungs; a greater benefit was obtained for OT. The current study demonstrated that the administration of OT as well as HBO as adjuvant therapy may support antibiotherapy in protecting the lung against septic injury. HBO and OT reduced tissue oxidative stress, regulated the systemic inflammatory response, and abated cellular infiltration to the lung demonstrated by findings of MPO activity and histopathologic examination. These findings indicated that OT tended to be more effective than HBO, in particular regarding serum IL-1β, lung GSH-Px and histologic outcome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.