ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2011
Tamoxifen increases nuclear respiratory factor 1 transcription by activating estrogen receptor beta and AP-1 recruitment to adjacent promoter binding sites.
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 31 citations in OpenAlex.
- Photoperiod, but not testosterone, increases basal metabolic rate in house sparrows.Integrative organismal biology (Oxford, England) · 2026Article
- Testosterone promotes photoreceptor degeneration in the sodium iodate model.Experimental eye research · 2025Article
- Identification of an ionic mechanism for ERα-mediated rapid excitation in neurons.Science advances · 2024Article
- Tamoxifen protects photoreceptors in the sodium iodate model.Experimental eye research · 2024Article
- The role of estrogen receptor beta in breast cancer.Biomarker research · 2020Review
- Impaired autophagic and mitochondrial functions are partially restored by ERT in Gaucher and Fabry diseases.PloS one · 2019Article
- Nuclear respiratory factor 1 promotes spheroid survival and mesenchymal transition in mammary epithelial cells.Oncogene · 2018Article
- Interplay between NRF1, E2F4 and MYC transcription factors regulating common target genes contributes to cancer development and progression.Cellular oncology (Dordrecht, Netherlands) · 2018Review
- Estrogens regulate life and death in mitochondria.Journal of bioenergetics and biomembranes · 2017Review
- Cytochrome c1 in ductal carcinoma in situ of breast associated with proliferation and comedo necrosis.Cancer science · 2017Article
- Membrane estrogen receptor 1 is required for normal reproduction in male and female mice.Journal of endocrinology and reproduction : JER · 2017Article
- Redox signalling to nuclear regulatory proteins by reactive oxygen species contributes to oestrogen-induced growth of breast cancer cells.British journal of cancer · 2015Article
- Bioenergetic differences between MCF-7 and T47D breast cancer cells and their regulation by oestradiol and tamoxifen.The Biochemical journal · 2015Article
- Effect of nonpersistent pesticides on estrogen receptor, androgen receptor, and aryl hydrocarbon receptor.Environmental toxicology · 2014Article
- β-D-glucan inhibits endocrine-resistant breast cancer cell proliferation and alters gene expression.International journal of oncology · 2014Article
- Mitochondrial and sex steroid hormone crosstalk during aging.Longevity & healthspan · 2014Article
- Assessment of cytochrome C oxidase dysfunction in the substantia nigra/ventral tegmental area in schizophrenia.PloS one · 2014Article
- Estradiol and tamoxifen regulate NRF-1 and mitochondrial function in mouse mammary gland and uterus.Journal of molecular endocrinology · 2013Article
- Estrogen receptor α mediates proliferation of osteoblastic cells stimulated by estrogen and mechanical strain, but their acute down-regulation of the Wnt antagonist Sost is mediated by estrogen receptor β.The Journal of biological chemistry · 2013Article
- DHEA metabolites activate estrogen receptors alpha and beta.Steroids · 2013Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Little is known about endogenous estrogen receptor β (ERβ) gene targets in human breast cancer. We reported that estradiol (E(2)) induces nuclear respiratory factor-1 (NRF-1) transcription through ERα in MCF-7 breast cancer cells. Here we report that 4-hydroxytamoxifen (4-OHT), with an EC(50) of ~1.7 nM, increases NRF-1 expression by recruiting ERβ, cJun, cFos, CBP, and RNA polymerase II to and dismissing NCoR from the NRF1 promoter. Promoter deletion and transient transfection studies showed that the estrogen response element (ERE) is essential and that an adjacent AP-1 site contributes to maximal 4-OHT-induced NRF-1 transcription. siRNA knockdown of ERβ revealed that ERβ inhibits basal NRF-1 expression and is required for 4-OHT-induced NRF-1 transcription. An AP-1 inhibitor blocked 4-OHT-induced NRF-1 expression. The 4-OHT-induced increase in NRF-1 resulted in increased transcription of NRF-1 target CAPNS1 but not CYC1, CYC2, or TFAM despite increased NRF-1 coactivator PGC-1α protein. The absence of TFAM induction corresponds to a lack of Akt-dependent phosphorylation of NRF-1 with 4-OHT treatment. Overexpression of NRF-1 inhibited 4-OHT-induced apoptosis and siRNA knockdown of NRF-1 increased apoptosis, indicating an antiapoptotic role for NRF-1. Overall, NRF-1 expression and activity is regulated by 4-OHT via endogenous ERβ in MCF-7 cells.
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