Evidence map›Paper›PMID 21233317›Full record

ArticleBlood2011

SNP rs6457327 in the HLA region on chromosome 6p is predictive of the transformation of follicular lymphoma.

David Wrench, Pamela Leighton, Christine F Skibola, Lucia Conde, Jean-Baptiste Cazier, Janet Matthews, Sameena Iqbal, Emanuela Carlotti, Csaba Bödör, Silvia Montoto and 4 more

Abstract read
In one paragraph

Article in Blood, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Risk Factors of Follicular Lymphoma.Expert opinion on medical diagnostics · 2012
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

David WrenchCentre for Haemato-Oncology, Barts Cancer Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK. d.j.wrench@qmul.ac.uk
Pamela Leighton
Christine F Skibola
Lucia Conde
Jean-Baptiste Cazier
Janet Matthews
Sameena Iqbal
Emanuela Carlotti
Csaba Bödör
Silvia Montoto
Maria Calaminici
John G Gribben
T Andrew Lister
Jude Fitzgibbon

Funding

A Genome-Wide Association Study of Non-Hodgkin LymphomaR01CA122663 · NCI · UNIVERSITY OF CALIFORNIA BERKELEY · PI SKIBOLA, CHRISTINE F. · 2006 to 2010
$2.7M
Genetic Susceptibility to Non-Hodgkins LymphomaR01CA104682 · NCI · UNIVERSITY OF CALIFORNIA BERKELEY · PI SKIBOLA, CHRISTINE F. · 2003 to 2012
$2.6M
Cancer Research UK C1574/A6806;NCI NIH HHS CA104682NCI NIH HHS CA122663NCI NIH HHS R01 CA104682NCI NIH HHS R01 CA122663Wellcome TrustWellcome Trust 075491/Z/04Wellcome Trust 076113Wellcome Trust 085475
6 · The paper itself

Abstract

Inherited risk determinants for follicular lymphoma (FL) have recently been described in the immune gene-rich human leukocyte antigen region on chromosome 6p. The known importance of host immune response to FL survival led us to evaluate these germline factors in FL outcome. We confirm the association of single nucleotide polymorphisms rs10484561 (P = 3.5 × 10⁻⁹) and rs6457327 (P = .008) with risk of FL and demonstrate that rs6457327 predicts both time to (P = .02) and risk of (P < .01) FL transformation independently of clinical variables, including the Follicular Lymphoma International Prognostic Index.

Indexed as

Cell Transformation, NeoplasticChromosomes, Human, Pair 6HLA AntigensHumansLymphoma, FollicularMiddle AgedPolymorphism, Single NucleotideRisk FactorsTime FactorsUnited KingdomHLA Antigens

Identifiers

PMID21233317
PMCPMC3062316

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.