ArticleInternational immunology2011
The WSX-1 pathway restrains intestinal T-cell immunity.
Article in International immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 10 citations in OpenAlex.
- Responses to LPS boost effector CD8 T-cell accumulation outside of signals 1 and 2.Cellular & molecular immunology · 2017Article
- Interleukin-27 as a Novel Therapy for Inflammatory Bowel Disease: A Critical Review of the Literature.Inflammatory bowel diseases · 2016Review
- Characterizing the inflammatory response in esophageal mucosal biopsies in children with eosinophilic esophagitis.Clinical & translational immunology · 2016Article
- New directions in the basic and translational biology of interleukin-27.Trends in immunology · 2012Review
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Mechanisms regulating intestinal T-cell accumulation during inflammation have considerable therapeutic value. In this study, LPS increased Staphylococcus aureus enterotoxin A-specific T cells in the gut through induction of IL-12 family members. Mice deficient in IL-12 (p35(-/-)) favored T(h)17 differentiation in lamina propria, whereas mice lacking both IL-12 and IL-23 (p40(-/-)) produced significantly fewer T(h)17 cells. However, serum analysis revealed that IL-27p28 was much higher and sustained following LPS injection than other IL-12 family cytokines. Strikingly, WSX-1 (IL-27Rα) deficiency resulted in log-fold increases in lamina propria T(h)17 cells without affecting T(h)1 numbers. These results may be explained by increased expression of α4β7 on WSX-1-deficient T cells after immunization. WSX-1-deficient regulatory T cells (Tregs) were also perturbed, producing more IL-17 and less IL-10 than wild-type Tregs. Thus, IL-27 blockade may provide a new pathway to improve mucosal vaccination.
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Registered trials
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