ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2011
Evaluation of 18F-FDG PET and MRI associations in pediatric diffuse intrinsic brain stem glioma: a report from the Pediatric Brain Tumor Consortium.
Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 44 citations in OpenAlex.
- Hyperpolarized Carbon-13 Metabolic Imaging Differentiates Distinctive Molecular Phenotypes in Diffuse Midline Gliomas.Molecules (Basel, Switzerland) · 2025Article
- Contemporary Management of Pediatric Brainstem Tumors.Advances and technical standards in neurosurgery · 2024Review
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- Joint EANM/SIOPE/RAPNO practice guidelines/SNMMI procedure standards for imaging of paediatric gliomas using PET with radiolabelled amino acids and [European journal of nuclear medicine and molecular imaging · 2022Article
- Pediatric Diffuse Midline Gliomas: An Unfinished Puzzle.Diagnostics (Basel, Switzerland) · 2022Review
- The Role of PET in Supratentorial and Infratentorial Pediatric Brain Tumors.Current oncology (Toronto, Ont.) · 2021Review
- Correlation of multimodalTheranostics · 2020Article
- Molecular Imaging in Pediatric Brain Tumors.Cancers · 2019Review
- Evaluation ofJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2019Article
- Conventional and Advanced Imaging of Diffuse Intrinsic Pontine Glioma.Journal of child neurology · 2016Review
- Apparent diffusion coefficient histogram metrics correlate with survival in diffuse intrinsic pontine glioma: a report from the Pediatric Brain Tumor Consortium.Neuro-oncology · 2016Article
- Pediatric brain tumors.Pediatric radiology · 2015Review
- A phase I trial and PK study of cediranib (AZD2171), an orally bioavailable pan-VEGFR inhibitor, in children with recurrent or refractory primary CNS tumors.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2015Article
- Clinical assessment of MR-guided 3-class and 4-class attenuation correction in PET/MR.Molecular imaging and biology · 2015Article
- Survival prediction model of children with diffuse intrinsic pontine glioma based on clinical and radiological criteria.Neuro-oncology · 2015Article
- Temozolomide after radiotherapy in recurrent "low grade" diffuse brainstem glioma in adults.Journal of neuro-oncology · 2014Article
- 18F-FDG PET and MR imaging associations across a spectrum of pediatric brain tumors: a report from the pediatric brain tumor consortium.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2014Article
- Diffuse intrinsic pontine glioma: a reassessment.Journal of neuro-oncology · 2014Review
- 18 F-FDG PET standard uptake values of the normal pons in children: establishing a reference value for diffuse intrinsic pontine glioma.EJNMMI research · 2014Article
- Exploratory evaluation of MR permeability with 18F-FDG PET mapping in pediatric brain tumors: a report from the Pediatric Brain Tumor Consortium.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2013Article
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Authors and funding
13 authors at 8 institutions in 1 country.
Funding
Abstract
unlabelledThe purpose of this study was to assess (18)F-FDG uptake in children with a newly diagnosed diffuse intrinsic brain stem glioma (BSG) and to investigate associations with progression-free survival (PFS), overall survival (OS), and MRI indices.
methodsTwo Pediatric Brain Tumor Consortium (PBTC) therapeutic trials in children with newly diagnosed BSG were designed to test radiation therapy combined with molecularly targeted agents (PBTC-007: phase I/II study of gefitinib; PBTC-014: phase I/II study of tipifarnib). Baseline brain (18)F-FDG PET scans were obtained in 40 children in these trials. Images were evaluated by consensus between 2 PET experts for intensity and uniformity of tracer uptake. Associations of (18)F-FDG uptake intensity and uniformity with both PFS and OS, as well as associations with tumor MRI indices at baseline (tumor volume on fluid-attenuated inversion recovery, baseline intratumoral enhancement, diffusion and perfusion values), were evaluated.
resultsIn most of the children, BSG (18)F-FDG uptake was less than gray-matter uptake. Survival was poor, irrespective of intensity of (18)F-FDG uptake, with no association between intensity of (18)F-FDG uptake and PFS or OS. However, hyperintense (18)F-FDG uptake in the tumor, compared with gray matter, suggested poorer survival rates. Patients with (18)F-FDG uptake in 50% or more of the tumor had shorter PFS and OS than did patients with (18)F-FDG uptake in less than 50% of the tumor. There was some evidence that tumors with higher (18)F-FDG uptake were more likely to show enhancement, and when the diffusion ratio was lower, the uniformity of (18)F-FDG uptake appeared higher.
conclusionChildren with BSG for which (18)F-FDG uptake involves at least half the tumor appear to have poorer survival than children with uptake in less than 50% of the tumor. A larger independent study is needed to verify this hypothesis. Intense tracer uptake in the tumors, compared with gray matter, suggests decreased survival. Higher (18)F-FDG uptake within the tumor was associated with enhancement on MR images. Increased tumor cellularity as reflected by restricted MRI diffusion may be associated with increased (18)F-FDG uniformity throughout the tumor.
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