SynthesisBMJ (Clinical research ed.)2011
Use of weaning protocols for reducing duration of mechanical ventilation in critically ill adult patients: Cochrane systematic review and meta-analysis.
Synthesis in BMJ (Clinical research ed.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 76 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
WEAN SAFE (WorldwidE AssessmeNt of Separation of pAtients From Ventilatory assistancE)
Weaning Algorithm for Mechanical VEntilation (WAVE Study): A Randomised Control Trial Comparing an Open-loop Decision Support System Versus Routine Care for Weaning From Mechanical Ventilation in the Cardiothoracic Intensive Care Unit
Who cites it
76 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- AARC Clinical Practice Guideline: Spontaneous Breathing Trials for Liberation From Adult Mechanical Ventilation.Respiratory care · 2024Guideline
- Clinical predictive models for recurrence and survival in treated laryngeal and hypopharyngeal cancer: a systematic review and meta-analysis.Frontiers in oncology · 2024Pooled it
- Effect of different levels of PEEP on mortality in ICU patients without acute respiratory distress syndrome: systematic review and meta-analysis with trial sequential analysis.Journal of critical care · 2021Pooled it
- [S3 Guideline Sepsis-prevention, diagnosis, therapy, and aftercare : Long version].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2020Guideline
- Non-invasive ventilation as a strategy for weaning from invasive mechanical ventilation: a systematic review and Bayesian meta-analysis.Intensive care medicine · 2018Pooled it
- Brazilian recommendations of mechanical ventilation 2013. Part 2.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia · 2014Guideline
- Small studies may overestimate the effect sizes in critical care meta-analyses: a meta-epidemiological study.Critical care (London, England) · 2013Pooled it
- Electrical Impedance Tomography-Guided Airway Clearance in Elderly Patients With Severe Pneumonia: A Prospective Study.The clinical respiratory journal · 2025Trial
- Trial
- Smart Care™ versus respiratory physiotherapy-driven manual weaning for critically ill adult patients: a randomized controlled trial.Critical care (London, England) · 2015Trial
- Trial
- Machine learning models predicting extubation success in mechanically ventilated patients: a systematic review and meta-analysis.Intensive care medicine experimental · 2026Review
- Characteristics of ventilator weaning in patients intubated for Guillain-Barré syndrome or myasthenia gravis: a nationwide multicenter study.Intensive care medicine · 2025Article
- Mechanical Power to Predict Ventilator Liberation in Patients With a Tracheostomy.Respiratory care · 2025Article
- Developing and validating machine learning models to predict next-day extubation.Scientific reports · 2025Article
- Non-Invasive Ventilation: When, Where, How to Start, and How to Stop.Journal of clinical medicine · 2025Review
- Weaning from mechanical ventilation in myasthenic crisis according to WEAN safe: most patients experience intermediate or prolonged weaning with no differences between early and late-onset compared to very-late onset myasthenia Gravis.Annals of intensive care · 2025Article
- Prediction of Spontaneous Breathing Trial Outcome in Critically Ill-Ventilated Patients Using Deep Learning: Development and Verification Study.JMIR medical informatics · 2025Article
- Multidisciplinary collaborative approach to cardiopulmonary rehabilitation in cancer patients with intensive care unit-acquired weakness: a clinical efficacy and safety analysis.American journal of cancer research · 2025Article
- Effectiveness of Evidence-Based Continuous Quality Improvement in Reducing Peripherally Inserted Central Catheter Complications Among Premature Infants in China: A Four-Year Retrospective Study.Journal of multidisciplinary healthcare · 2025Article
16 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the effects of weaning protocols on the total duration of mechanical ventilation, mortality, adverse events, quality of life, weaning duration, and length of stay in the intensive care unit and hospital.
designSystematic review. DATA SOURCES: Cochrane Central Register of Controlled Trials, Medline, Embase, CINAHL, LILACS, ISI Web of Science, ISI Conference Proceedings, Cambridge Scientific Abstracts, and reference lists of articles. We did not apply language restrictions. Review methods We included randomised and quasi-randomised controlled trials of weaning from mechanical ventilation with and without protocols in critically ill adults. Data selection Three authors independently assessed trial quality and extracted data. A priori subgroup and sensitivity analyses were performed. We contacted study authors for additional information.
resultsEleven trials that included 1971 patients met the inclusion criteria. Compared with usual care, the geometric mean duration of mechanical ventilation in the weaning protocol group was reduced by 25% (95% confidence interval 9% to 39%, P=0.006; 10 trials); the duration of weaning was reduced by 78% (31% to 93%, P=0.009; six trials); and stay in the intensive care unit length by 10% (2% to 19%, P=0.02; eight trials). There was significant heterogeneity among studies for total duration of mechanical ventilation (I(2)=76%, P<0.01) and duration of weaning (I(2)=97%, P<0.01), which could not be explained by subgroup analyses based on type of unit or type of approach.
conclusionThere is evidence of a reduction in the duration of mechanical ventilation, weaning, and stay in the intensive care unit when standardised weaning protocols are used, but there is significant heterogeneity among studies and an insufficient number of studies to investigate the source of this heterogeneity. Some studies suggest that organisational context could influence outcomes, but this could not be evaluated as it was outside the scope of this review.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.