Evidence map›Paper›PMID 21233079›Full record

ArticleArchives of disease in childhood2011

Evaluation of temperature-pulse centile charts in identifying serious bacterial illness: observational cohort study.

Andrew J Brent, Monica Lakhanpaul, Nelly Ninis, Michael Levin, Roddy MacFaul, Matthew Thompson

Open access · bronzeAbstract readEvaluation StudyMulticenter Study
In one paragraph

Article in Archives of disease in childhood, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 29 citations in OpenAlex.

  1. Trial
  2. A primary healthcare approach to children with fever.South African family practice : official journal of the South African Academy of Family Practice/Primary Care · 2026
    Article
  3. Article
  4. Observational
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  7. Article
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  9. Article
  10. Observational
  11. Article
  12. Fever in Children: Pearls and Pitfalls.Children (Basel, Switzerland) · 2017
    Review
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 3 countries.

Andrew J BrentWorking Group on Recognising Acute Illness in Children, Royal College of Paediatrics and Child Health, London, UK. dr.a.brent@gmail.com
Monica Lakhanpaul
Nelly Ninis
Michael Levin
Roddy MacFaul
Matthew Thompson
Royal College of Paediatrics and Child Health · GBImperial College London · GBKenya Medical Research Institute · KEUniversity of Leicester · GBUniversity of Oxford · GB

Funding

Medical Research Council G0000340Wellcome TrustWellcome Trust 081697
6 · The paper itself

Abstract

backgroundDistinguishing serious bacterial infection (SBI) from milder/self-limiting infections is often difficult. Interpretation of vital signs is confounded by the effect of temperature on pulse and respiratory rate. Temperature-pulse centile charts have been proposed to improve the predictive value of pulse rate in the clinical assessment of children with suspected SBI.

objectivesTo assess the utility of proposed temperature-pulse centile charts in the clinical assessment of children with suspected SBI. STUDY DESIGN AND

participantsThe predictive value for SBI of temperature-pulse centile categories, pulse centile categories and Advanced Paediatric Life Support (APLS) defined tachycardia were compared among 1360 children aged 3 months to 10 years presenting with suspected infection to a hospital emergency department (ED) in England; and among 325 children who presented to hospitals in the UK with meningococcal disease.

main outcome measureSBI.

resultsAmong children presenting to the ED, 55 (4.0%) had SBI. Pulse centile category, but not temperature-pulse centile category, was strongly associated with risk of SBI (p=0.0005 and 0.288, respectively). APLS defined tachycardia was also strongly associated with SBI (OR 2.90 (95% CI 1.60 to 5.26), p=0.0002). Among children with meningococcal disease, higher pulse and temperature-pulse centile categories were both associated with more severe disease (p=0.004 and 0.041, respectively).

conclusionsIncreased pulse rate is an important predictor of SBI, supporting National Institute for Health and Clinical Excellence recommendations that pulse rate be routinely measured in the assessment of febrile children. Temperature-pulse centile charts performed more poorly than pulse alone in this study. Further studies are required to evaluate their utility in monitoring the clinical progress of sick children over time.

Indexed as

Bacterial InfectionsBody TemperatureChildChild, PreschoolDiagnosis, DifferentialEmergency Service, HospitalEpidemiologic MethodsFemaleHeart RateHumansInfantMaleMeningococcal InfectionsReference ValuesSepsisTachycardia

Identifiers

PMID21233079
PMCPMC3158667
OpenAlexW2097945385

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.