Evidence map›Paper›PMID 21232524›Full record

ReviewArchives of biochemistry and biophysics2011

Pathogenesis of nonmelanoma skin cancers in organ transplant recipients.

Mohammad Athar, Stephanie B Walsh, Levy Kopelovich, Craig A Elmets

Abstract readReview
In one paragraph

Review in Archives of biochemistry and biophysics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 61 citations in OpenAlex.

  1. Article
  2. Review
  3. Cemiplimab for Kidney Transplant Recipients With Advanced Cutaneous Squamous Cell Carcinoma.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2024
    Article
  4. Review
  5. An update on clinical trials for chemoprevention of human skin cancer.Journal of cancer metastasis and treatment · 2023
    Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Mohammad AtharDepartment of Dermatology and Skin Diseases Research Center, University of Alabama at Birmingham, Birmingham, AL 35294-0019, USA. mathar@uab.edu
Stephanie B Walsh
Levy Kopelovich
Craig A Elmets
University of Alabama at Birmingham · USNational Cancer Institute · USUniversity of Alabama at Birmingham Hospital · US

Funding

UAB Skin Diseases Research CenterP30AR050948 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ELMETS, CRAIG A · 2004 to 2013
$5.5M
Role of p53 and ptc tumor suppressive pathways in BCCs development and preventionR01ES015323 · NIEHS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ATHAR, MOHAMMAD · 2006 to 2010
$1.7M
Inhibiting Multiple Molecular Targets for Preventing Non-Melanoma Skin CancerR01CA138998 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ATHAR, MOHAMMAD · 2011 to 2015
$1.5M
Training in Investigative DermatologyT32AR053458 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ELMETS, CRAIG A · 2006 to 2010
$861k
Developing a murine model for arsenic-induced skin neoplasmR21ES017494 · NIEHS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ATHAR, MOHAMMAD · 2009 to 2010
$401k
NCI NIH HHS N01 CN043301NCI NIH HHS N01-CN-43300NCI NIH HHS R01 CA138998NIAMS NIH HHS P30 AR050948NIAMS NIH HHS T32 AR053458NIEHS NIH HHS R01 ES015323NIEHS NIH HHS R21 ES017494
6 · The paper itself

Abstract

Nonmelanoma skin cancer (NMSC) is the most common human cancer, with an incidence of more than 1.2 million per year in the USA. The risk for the development of NMSCs increases by approximately 10-250 fold in chronically immune suppressed organ transplant recipients (OTRs). Solar UVB is the most common etiologic factor in the development of this neoplasm, both in immune competent and immune suppressed populations. This review provides a description of NMSC in OTRs. It also provides an account of the various immunologic and non-immune-dependent mechanisms involved in the pathogenesis and progression of NMSCs in OTRs. Finally, this review addresses possible strategies for the prevention of this cancer, particularly focusing on the aspects that may be incorporated to prevent negative effects of chemopreventive chemicals on graft survival.

Indexed as

AnimalsCyclooxygenase InhibitorsHumansImmunosuppressive AgentsOrgan TransplantationOrnithine Decarboxylase InhibitorsRetinoidsSkin NeoplasmsCyclooxygenase InhibitorsImmunosuppressive AgentsOrnithine Decarboxylase InhibitorsRetinoids

Identifiers

PMID21232524
PMCPMC3063391
OpenAlexW2067661888

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.