ArticleGenome biology2011
Ligand-dependent dynamics of retinoic acid receptor binding during early neurogenesis.
Article in Genome biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.
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Who cites it
70 citing papers in PubMed, 138 citations in OpenAlex.
- Simulation-guided chemical direct reprogramming informed by temporal cellular conversion processes at the single-cell level.Communications chemistry · 2026Article
- A controllable human spinal cord model with full dorsoventral patterning.Nature communications · 2026Article
- Axon targeting of transcriptionally distinct pioneer neurons is regulated by retinoic acid signaling.Nature communications · 2025Article
- Effects of Bisphenol A and Retinoic Acid Exposure on Neuron and Brain Formation: A Study in Human Induced Pluripotent Stem Cells and Zebrafish Embryos.Environmental health perspectives · 2025Article
- Threshold Effects of Third-Trimester Maternal Vitamin A on Neonatal Ponderal Index: A Segmented Regression Analysis of 442 Mother-Infant Pairs.Food science & nutrition · 2025Article
- Meningeal-derived retinoic acid regulates neurogenesis via suppression of Notch and Sox2.Cell reports · 2025Article
- Feedback regulation of retinaldehyde reductase DHRS3, a critical determinant of retinoic acid homeostasis.FEBS letters · 2025Article
- Non-canonical retinoid signaling in neural development, regeneration and synaptic function.Frontiers in molecular neuroscience · 2024Review
- Retinoid X receptor heterodimers in hepatic function: structural insights and therapeutic potential.Frontiers in pharmacology · 2024Review
- Generation of functional posterior spinal motor neurons from hPSCs-derived human spinal cord neural progenitor cells.Cell regeneration (London, England) · 2023Article
- One model fits all: Combining inference and simulation of gene regulatory networks.PLoS computational biology · 2023Article
- Topological morphogenesis of neuroepithelial organoids.Nature physics · 2023Article
- Synthetic regulatory reconstitution reveals principles of mammalianScience (New York, N.Y.) · 2022Article
- Identification of downstream effectors of retinoic acid specifying the zebrafish pancreas by integrative genomics.Scientific reports · 2021Article
- Global Transcriptional Analyses of the Wnt-Induced Development of Neural Stem Cells from Human Pluripotent Stem Cells.International journal of molecular sciences · 2021Article
- Pontin Functions as A Transcriptional Co-activator for Retinoic Acid-induced HOX Gene Expression.Journal of molecular biology · 2021Article
- An interpretable bimodal neural network characterizes the sequence and preexisting chromatin predictors of induced transcription factor binding.Genome biology · 2021Article
- Structural basis for DNA recognition and allosteric control of the retinoic acid receptors RAR-RXR.Nucleic acids research · 2020Article
- Sequence and chromatin determinants of transcription factor binding and the establishment of cell type-specific binding patterns.Biochimica et biophysica acta. Gene regulatory mechanisms · 2020Review
- Evolving Role of RING1 and YY1 Binding Protein in the Regulation of Germ-Cell-Specific Transcription.Genes · 2019Review
10 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundAmong its many roles in development, retinoic acid determines the anterior-posterior identity of differentiating motor neurons by activating retinoic acid receptor (RAR)-mediated transcription. RAR is thought to bind the genome constitutively, and only induce transcription in the presence of the retinoid ligand. However, little is known about where RAR binds to the genome or how it selects target sites.
resultsWe tested the constitutive RAR binding model using the retinoic acid-driven differentiation of mouse embryonic stem cells into differentiated motor neurons. We find that retinoic acid treatment results in widespread changes in RAR genomic binding, including novel binding to genes directly responsible for anterior-posterior specification, as well as the subsequent recruitment of the basal polymerase machinery. Finally, we discovered that the binding of transcription factors at the embryonic stem cell stage can accurately predict where in the genome RAR binds after initial differentiation.
conclusionsWe have characterized a ligand-dependent shift in RAR genomic occupancy at the initiation of neurogenesis. Our data also suggest that enhancers active in pluripotent embryonic stem cells may be preselecting regions that will be activated by RAR during neuronal differentiation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.