Evidence map›Paper›PMID 21230941›Full record

ArticlePhysical review letters2010

Remodeling of integrated contractile tissues and its dependence on strain-rate amplitude.

Madavi Oliver, Tímea Kováts, Srboljub M Mijailovich, James P Butler, Jeffrey J Fredberg, Guillaume Lenormand

Abstract read
In one paragraph

Article in Physical review letters, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Collective migration and cell jamming.Differentiation; research in biological diversity · 2013
    Review
  13. Article
  14. Emergence of airway smooth muscle functions related to structural malleability.Journal of applied physiology (Bethesda, Md. : 1985) · 2011
    Review
  15. Glass-like dynamics in the cell and in cellular collectives.Wiley interdisciplinary reviews. Systems biology and medicine
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Madavi OliverSchool of Public Health, Harvard University, Boston, Massachusetts 02115, USA.
Tímea Kováts
Srboljub M Mijailovich
James P Butler
Jeffrey J Fredberg
Guillaume Lenormand

Funding

Micromechanics of the airway smooth muscle cellR01HL065960 · NHLBI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI FREDBERG, JEFFREY J · 2000 to 2009
$6.3M
Mechanics of Monolayer MigrationR01HL107561 · NHLBI · HARVARD SCHOOL OF PUBLIC HEALTH · PI FREDBERG, JEFFREY J · 2011 to 2015
$3.1M
AIRWAY MECHANICS AND SMOOTH MUSCLE SHORTENINGR01HL059682 · NHLBI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI FREDBERG, JEFFREY J · 1998 to 2006
$2.7M
The resident cell in the asthmatic airway: A victim of its physical microenvironR01HL102373 · NHLBI · HARVARD SCHOOL OF PUBLIC HEALTH · PI FREDBERG, JEFFREY J, TSCHUMPERLIN, DANIEL J. · 2011 to 2014
$1.9M
Remodeling of the airway smooth muscle cellR01HL084224 · NHLBI · HARVARD SCHOOL OF PUBLIC HEALTH · PI FREDBERG, JEFFREY J · 2006 to 2009
$1.6M
NHLBI NIH HHS R01 HL059682NHLBI NIH HHS R01 HL065960NHLBI NIH HHS R01 HL084224NHLBI NIH HHS R01 HL102373NHLBI NIH HHS R01 HL107561
6 · The paper itself

Abstract

Here we investigate the origin of relaxation times governing the mechanical response of an integrated contractile tissue to imposed cyclic changes of length. When strain-rate amplitude is held constant as frequency is varied, fast events are accounted for by actomyosin cross-bridge cycling, but slow events reveal relaxation processes associated with ongoing cytoskeletal length adaptation. Although both relaxation regimes are innately nonlinear, these regimes are unified and their positions along the frequency axis are set by the imposed strain-rate amplitude.

Indexed as

Models, BiologicalAnimalsBiomechanical PhenomenaElastic ModulusIn Vitro TechniquesMuscle ContractionSheep

Identifiers

PMID21230941
PMCPMC3940190

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.