Evidence map›Paper›PMID 21229999›Full record

ArticleNano letters2011

Self-assembling RNA nanorings based on RNAI/II inverse kissing complexes.

Wade W Grabow, Paul Zakrevsky, Kirill A Afonin, Arkadiusz Chworos, Bruce A Shapiro, Luc Jaeger

Abstract read
In one paragraph

Article in Nano letters, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 123 papers.

0numbers the graph read from it
0cells of the map it votes in
123citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

123 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Molecular pharmaceutics · 2024
    Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Automated 3D Design and Evaluation of RNA Nanostructures with RNAMake.Methods in molecular biology (Clifton, N.J.) · 2023
    Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Review

63 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Wade W GrabowDepartment of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106-9510, USA.
Paul Zakrevsky
Kirill A Afonin
Arkadiusz Chworos
Bruce A Shapiro
Luc Jaeger

Funding

Computational RNA NanodesignZIABC011061 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI SHAPIRO, BRUCE · 2009 to 2021
$12.3M
Exploring the RNA syntax for engineering therapeutic RNA-based nano-factoriesR01GM079604 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI JAEGER, LUC · 2007 to 2011
$1.7M
Intramural NIH HHSNIGMS NIH HHS R01 GM079604NIGMS NIH HHS R01GM-079604
6 · The paper itself

Abstract

RNA is an attractive biopolymer for nanodesign of self-assembling particles for nanobiotechnology and synthetic biology. Here, we experimentally characterize by biochemical and biophysical methods the formation of thermostable and ribonuclease resistant RNA nanorings previously proposed by computational design. High yields of fully programmable nanorings were produced based on several RNAI/IIi kissing complex variants selected for their ability to promote polygon self-assembly. This self-assembly strategy relying on the particular geometry of bended kissing complexes has potential for developing short interfering RNA delivery agents.

Indexed as

CrystallizationMacromolecular SubstancesMaterials TestingNanostructuresNanotechnologyNucleic Acid ConformationParticle SizeRNASurface PropertiesMacromolecular SubstancesRNA

Identifiers

PMID21229999
PMCPMC3036768

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.