ReviewInternational urology and nephrology2012
Prevention of chronic kidney disease in spina bifida.
Review in International urology and nephrology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.
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Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it, 114 citations in OpenAlex.
- Upper and lower urinary tract outcomes in adult myelomeningocele patients: a systematic review.PloS one · 2012Pooled it
- Diagnostic Test Characteristics of Renal Ultrasound Findings for High-Risk Bladder in Spina Bifida.The Journal of urology · 2026Article
- Surgical treatment and outcomes of neural tube defects at the university of Gondar Comprehensive Specialized Hospital, Ethiopia: a two-year retrospective review.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026Article
- Chronic Kidney Disease Frequently Observed in Adults With Spina Bifida.International journal of urology : official journal of the Japanese Urological Association · 2026Article
- Children with recurrent urinary tract infections: who are they and why do we need better prevention options?BMC pediatrics · 2025Article
- Role of Combined Use of Adiponectin and hsCRP in Cardiovascular Risk in Pediatric Neurogenic Bladder.Children (Basel, Switzerland) · 2025Article
- Rewriting the urinary tract paradigm: the urobiome as a gatekeeper of host defense.Molecular biology reports · 2025Review
- Characteristics and predictors of chronic kidney disease in children with myelomeningocele: a nationwide cohort study.Pediatric nephrology (Berlin, Germany) · 2024Article
- Multidisciplinary management of people with spina bifida across the lifespan.Pediatric nephrology (Berlin, Germany) · 2024Review
- Spina bifida and cardiorespiratory profile: the impact of leisure sport activities on physical fitness.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Article
- Practice of clean intermittent catheterisation in children with spina bifida: A scoping review.African journal of disability · 2024Article
- Follow-up for the upper urinary tract in patients with high-risk neurogenic lower urinary tract dysfunction.World journal of urology · 2023Review
- Article
- Episodes of Febrile Urinary Tract Infections Occur More Often in the Winter in Patients with Spina Bifida.Urology research & practice · 2023Article
- Risk factors for upper urinary tract deterioration in adult patients with spina bifida.World journal of urology · 2023Article
- Pregnancy in spina bifida patients: a comparative analysis of peripartum procedures and complications.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023Article
- Survey on Untethering of the Spinal Cord and Urological Manifestations among Spina Bifida Patients in Malaysia.Children (Basel, Switzerland) · 2022Article
- The impact of constant antibiotic prophylaxis in children affected by spinal dysraphism performing clean intermittent catheterization: a 2-year monocentric retrospective analysis.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2022Article
- Contemporary Management of Urinary Tract Infections in Children.Current treatment options in pediatrics · 2022Review
- Lower urinary tract dysfunction in pediatrics progress to kidney disease in adolescents: Toward precision medicine in treatment.World journal of nephrology · 2021Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe prevalence of progressive chronic kidney disease (CKD) in children and adults with spina bifida is considerable, rising, and entirely preventable. REMOVING THE CAUSE: PREVENTION OF SPINA BIFIDA: The best prevention of CKD in spina bifida is prevention of spina bifida itself through strategies that include folate supplementation, ideally before pregnancy. THE CAUSE OF CKD: Dysfunctional bladder outlet causes febrile Urinary Tract Infections (UTI), even with clean intermittent catheterization (CIC), and subsequent renal scarring. The development of secondary vesicoureteric reflux (VUR) increases the risk of renal scarring and CKD. FINDING THE IDEAL MARKER FOR MEASUREMENT OF RENAL FUNCTION IN SPINA BIFIDA: Creatinine-based methods are insensitive because of low muscle mass and underdeveloped musculature in the legs. Only Cystatin C-based eGFR can reliably assess global renal function in these patients. However, unilateral renal damage requires nuclear medicine scans, such as (99m)Tc DMSA. (VIDEO)URODYNAMICS STUDIES (UDS): Early treatment is recommended based on UDS with anticholinergics, CIC, and antibiotic prophylaxis when indicated. Overnight catheter drainage, Botox, and eventually augmentation cystoplasty are required for poorly compliant bladders. A continent child or one rendered continent following surgery is at a higher risk of renal damage.
conclusionA multidisciplinary approach is required to reduce the burden of CKD in patients with spina bifida. The right tools have to be utilized to monitor these patients, particularly if recurrent UTIs occur. Cystatin C eGFR is preferred for monitoring renal damage in these patients, and (99m)Tc DMSA scans have to be used to detect unilateral renal scarring.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.