ArticleJournal of gastroenterology2011
Risk factors for erosive esophagitis: a cross-sectional study of a large number of Japanese males.
Article in Journal of gastroenterology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 3 syntheses or guidelines pooled it, 71 citations in OpenAlex.
- Risk factors and 26-years worldwide prevalence of endoscopic erosive esophagitis from 1997 to 2022: a meta-analysis.Scientific reports · 2023Pooled it
- Central adiposity is associated with increased risk of esophageal inflammation, metaplasia, and adenocarcinoma: a systematic review and meta-analysis.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2013Pooled it
- Association between body mass index and erosive esophagitis: a meta-analysis.World journal of gastroenterology · 2012Pooled it
- Potential roles of Helicobacter pylori treatment, body mass index and waist circumference in the causation of erosive esophagitis: a randomized clinical trial (HEROES-GERD).International journal of obesity (2005) · 2020Trial
- The Association between Smoking Exposure and Reflux Esophagitis: A Cross-sectional Study among Men Conducted as a Part of Health Screening.Internal medicine (Tokyo, Japan) · 2023Article
- Disease trends afterWorld journal of gastroenterology · 2023Article
- Comparison of the role of alcohol consumption and qualitative abdominal fat on NAFLD and MAFLD in males and females.Scientific reports · 2022Article
- Predictive Factors for Future Onset of Reflux Esophagitis: A Longitudinal Case-control Study Using Health Checkup Records.Journal of neurogastroenterology and motility · 2022Article
- Management of Helicobacter pylori infection: The Bhubaneswar Consensus Report of the Indian Society of Gastroenterology.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2021Article
- The relationship betweenTherapeutic advances in gastroenterology · 2021Article
- Relationship between gastroesophageal reflux disease (GERD) and constipation: laxative use is common in GERD patients.Esophagus : official journal of the Japan Esophageal Society · 2021Observational
- Clinical features and therapeutic responses to proton pump inhibitor in patients with severe reflux esophagitis: A multicenter prospective observational study.JGH open : an open access journal of gastroenterology and hepatology · 2021Article
- Differences in Several Factors in the Development of Erosive Esophagitis Among Patients at Various Stages of Metabolic Syndrome: A Cross-Sectional Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Article
- Spectrum of esophageal motility disorders in patients with liver cirrhosis.World journal of hepatology · 2020Review
- Influence of sex on the association between body mass index and frequency of upper gastrointestinal symptoms.JGH open : an open access journal of gastroenterology and hepatology · 2020Article
- Prevalence Rate and Predictive Factors of Pancreatic Diseases in Cases with Pancreatic Duct Dilatation: A Cross-sectional Study of a Large, Healthy Japanese Population.Internal medicine (Tokyo, Japan) · 2020Article
- Association between visceral abdominal obesity and long-segment Barrett's esophagus in a Japanese population.Journal of gastroenterology · 2020Article
- Prevalence of and Risk Factors for Diseases in Korean Americans and Native Koreans Undergoing Health Checkup.Korean journal of family medicine · 2019Article
- Article
- Alcohol accumulation promotes esophagitis via pyroptosis activation.International journal of biological sciences · 2018Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe impact of obesity on gastroesophageal reflux disease remains controversial. We undertook this study, with a large sample size, to investigate risk factors for endoscopic erosive esophagitis by multivariate analysis, including visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) as covariates.
methodsJapanese males who visited our institute for a comprehensive medical survey between 2007 and 2010 were enrolled. All subjects voluntarily participated in a self-paid health check-up program including blood test screening, physical examinations, and esophagogastroduodenoscopy. VAT and SAT were measured by computed tomography at the navel level. Independent and significant predictors of erosive esophagitis were determined by multivariate analysis.
resultsOf 9840 eligible subjects, 1831 (18.6%) were diagnosed with erosive esophagitis. Body mass index and triglyceride were predictors of an increased prevalence of erosive esophagitis (odds ratios [ORs] = 1.063 and 1.001; 95% confidence intervals [CIs] = 1.020-1.108 and 1.001-1.002; p = 0.004 and <0.001, respectively). Heavy alcohol consumption, heavy smoking, and hiatal hernia were also associated with an increased prevalence of erosive esophagitis (ORs = 1.276, 1.399, and 2.758; 95% CIs = 1.085-1.501, 1.220-1.605, and 2.474-3.075; p < 0.001 for all). Helicobacter pylori infection significantly and independently decreased the prevalence of erosive esophagitis (OR = 0.346, 95% CI = 0.299-0.401, p < 0.001). Central obesity, as determined by VAT and waist girth, did not confer an increased risk of erosive esophagitis after adjusting for confounders.
conclusionsLifestyle factors including heavy alcohol consumption, heavy smoking, metabolic disorders, and hiatal hernia increased the risk of erosive esophagitis, but central obesity did not.
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