ArticleClinical reviews in allergy & immunology2012
Geographical differences in autoantibodies and anti-infectious agents antibodies among healthy adults.
Article in Clinical reviews in allergy & immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
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Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- Predictors of Epstein-Barr virus serostatus and implications for vaccine policy: A systematic review of the literature.Journal of global health · 2020Pooled it
- Prevalence of celiac disease in latin america: a systematic review and meta-regression.PloS one · 2015Pooled it
- Environmental pollution, apolipoprotein A-1 autoantibodies and cardiovascular risk: evidence from a geospatial cross-sectional study.Atherosclerosis plus · 2026Article
- Epstein-Barr virus seroprevalence among inflammatory bowel disease patients in Saudi Arabia.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association · 2024Article
- Article
- Detection of G Protein-Coupled Receptor Autoantibodies in Postural Orthostatic Tachycardia Syndrome Using Standard Methodology.Circulation · 2022Article
- Autoantibodies in severe COVID-19-related acute respiratory distress syndrome: Just innocent bystanders?International journal of rheumatic diseases · 2021Article
- Antinuclear Autoantibodies in Health: Autoimmunity Is Not a Synonym of Autoimmune Disease.Antibodies (Basel, Switzerland) · 2021Review
- C-reactive protein in traditional melanesians on Kitava.BMC cardiovascular disorders · 2020Article
- Autoimmunity as the comet tail of COVID-19 pandemic.World journal of clinical cases · 2020Review
- Seroprevalences of autoantibodies and anti-infectious antibodies among Ghana's healthy population.Scientific reports · 2020Article
- Occurrence of anti-CCP2 and RF isotypes and their relation to age and disease severity among Sudanese patients with rheumatoid arthritis.Clinical rheumatology · 2019Article
- HLA-DRB1 the notorious gene in the mosaic of autoimmunity.Immunologic research · 2017Article
- Antinuclear antibody prevalence in a general pediatric cohort from Mexico City: discordance between immunofluorescence and multiplex assays.Clinical epidemiology · 2017Article
- Prevalence of positive autoimmune biomarkers in the brucellosis patients.Clinical rheumatology · 2016Article
- Genetics of Autoimmune Thyroiditis in Type 1 Diabetes Reveals a Novel Association With DPB1*0201: Data From the Type 1 Diabetes Genetics Consortium.Diabetes care · 2015Article
- The prevalence of antinuclear antibodies in the general population of china: a cross-sectional study.Current therapeutic research, clinical and experimental · 2014Article
- Hodgkin lymphoma incidence in California Hispanics: influence of nativity and tumor Epstein-Barr virus.Cancer causes & control : CCC · 2014Article
- The spectrum between antiphospholipid syndrome and systemic lupus erythematosus.Clinical rheumatology · 2014Article
- Vitamin D Levels Are Associated with Expression of SLE, but Not Flare Frequency.International journal of rheumatology · 2014Article
Corrections and comments
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Authors and funding
14 authors at 8 institutions in 7 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Much is known about the geoepidemiology of defined autoimmune diseases (AD); however, there is currently limited data regarding the prevalence of autoantibodies among healthy populations of different geographical areas. The aim of this study was to evaluate a large profile of autoantibodies in healthy adults from distinct global regions as well as the prevalence of anti-infectious agents antibodies in those regions. Sera samples from 557 healthy donors were obtained at six centers located in different countries (i.e., Italy, Netherlands, Israel, Mexico, Columbia, Papua New Guinea (Kitavans)). Sera were tested for the presence of antinuclear antibodies (ANA) and autoantibodies associated with thrombophilia, vasculitis, and gastrointestinal (GI) disease. Sera samples were also screened for antibodies against infectious agents (i.e., EBV, CMV, HBV, Helicobacter pylori, Treponema pallidum, and Toxoplasma gondii). Tests were performed using the BioPlex 2200 or ELISA kits (Bio-Rad Laboratories, USA). We found a significant gradient of ANA positivity among the groups: 45% of Columbians, 38% of Kitavans, 26% of Mexicans, 12% of Italians, 12% of Dutch, and 11% of Israelis were ANA positive. Geographical differences were also observed regarding the prevalence of specific autoantibodies, namely ANA: anti-dsDNA, chromatin, SmRNP, Ro/SSA, La/SSB, Scl70; GI associated: antigliadin; and thrombophilia-associated: anti-β2GP1 and prothrombin. Additionally, significant differences were observed regarding serological markers of all infectious agents screened. The observed variance between healthy ethno-geographical distinct populations in prevalence of autoantibodies may represent different genetic or environmental (e.g., prior exposure to infection) influences. Thus may illuminate possible causes of geoepidemiological differences in AD.
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