Evidence map›Paper›PMID 21229178›Full record

ArticleMolecular bioSystems2011

Localization of antimicrobial peptides on polymerized liposomes leading to their enhanced efficacy against Pseudomonas aeruginosa.

Amit Kumar, Satya S Kolar, Meriong Zao, Alison M McDermott, Chengzhi Cai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular bioSystems, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Esculentin-1a(1-21)NH2: a frog skin-derived peptide for microbial keratitis.Cellular and molecular life sciences : CMLS · 2015
    Article
  6. Role of host-defence peptides in eye diseases.Cellular and molecular life sciences : CMLS · 2011
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Amit KumarDepartment of Chemistry, University of Houston, Houston, TX 77204, USA.
Satya S Kolar
Meriong Zao
Alison M McDermott
Chengzhi Cai
University of Houston · US

Funding

Nanoscale presentation of antimicrobial peptides found at the ocular surfaceR21EY018303 · NEI · UNIVERSITY OF HOUSTON · PI CAI, CHENGZHI · 2009 to 2010
$413k
NEI NIH HHS EY018303NEI NIH HHS R21 EY018303
6 · The paper itself

Abstract

Antimicrobial peptide IG-25 (a truncated version of LL-37 of the cathelicidin family) tethering an azido-capped poly(ethylene glycol) chain at the N-terminus was site-specifically attached to alkynyl-terminated polymerized liposomes using copper catalyzed "click" reaction, leading to an 18 fold enhancement in efficacy against Pseudomonas aeruginosa when compared to LL-37 without any increase in cytotoxicity to human corneal epithelial cells.

Indexed as

Anti-Bacterial AgentsAntimicrobial Cationic PeptidesCatalysisCathelicidinsClick ChemistryCopperCorneaEpithelial CellsHumansLiposomesMicrobial Sensitivity TestsMolecular StructurePolyethylene GlycolsPseudomonas aeruginosaStructure-Activity RelationshipAnti-Bacterial AgentsAntimicrobial Cationic PeptidesCathelicidinsCopperI-G-K-E-F-K-R-I-V-Q-R-I-K-D-F-L-R-N-L-V-P-R-T-E-SLiposomesPolyethylene Glycols

Identifiers

PMID21229178
PMCPMC3235330
OpenAlexW1997756269

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.