Evidence map›Paper›PMID 21228823›Full record

ArticleJournal of human hypertension2012

Subendocardial viability ratio as an index of impaired coronary flow reserve in hypertensives without significant coronary artery stenoses.

D Tsiachris, C Tsioufis, D Syrseloudis, D Roussos, I Tatsis, K Dimitriadis, K Toutouzas, E Tsiamis, C Stefanadis

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in Journal of human hypertension, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07719790 (Does Erectile Dysfonction is Correlated to Subendocardial Viability Among Treated Patients With Hypertension ?), which is not on this map. Cited by 55 papers.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07719790 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Does Erectile Dysfonction is Correlated to Subendocardial Viability Among Treated Patients With Hypertension ?

TypeobservationalSponsorAssistance Publique - Hôpitaux de ParisRan2026 to 2028Enrolled120ConditionsHypertension, Erectile Dysfunction
3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 128 citations in OpenAlex.

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  10. Prognostic value of exercise blood pressure: role of fitness and exercise training.American journal of physiology. Heart and circulatory physiology · 2026
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  16. A spectral machine learning approach to derive central aortic pressure waveforms from a brachial cuff.Proceedings of the National Academy of Sciences of the United States of America · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

D TsiachrisFirst Cardiology Clinic, University of Athens, Hippokration Hospital, Athens, Greece.
C Tsioufis
D Syrseloudis
D Roussos
I Tatsis
K Dimitriadis
K Toutouzas
E Tsiamis
C Stefanadis
National and Kapodistrian University of Athens · GRHippocration General Hospital · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Subendocardial viability ratio (SEVR), calculated through pulse wave analysis, is an index of myocardial oxygen supply and demand. Our aim was to evaluate the relationship between coronary flow reserve (CFR) and SEVR in 36 consecutive untreated hypertensives (aged 57.9 years, 12 males, all Caucasian) with indications of myocardial ischaemia and normal coronary arteries in coronary angiography. CFR was calculated by a 0.014-inch Doppler guidewire (Flowire, Volcano, San Diego, CA, USA) in response to bolus intracoronary administration of adenosine (30-60 μg). SEVR was calculated by radial applanation tonometry, while diastolic function was evaluated by means of transmitral flow and tissue Doppler imaging. Hypertensive patients with low CFR (n=24) compared with those with normal CFR (n=12) exhibited significantly decreased SEVR by 24.5% (P=0.002). In hypertensives with low CFR, CFR was correlated with SEVR (r=0.651, P=0.001). After applying multivariate linear regression analysis, age, left ventricular mass index, Em/Am, 24-h diastolic blood pressure (BP) and SEVR turned out to be the only independent predictors of CFR (adjusted R(2)=0.718). Estimation of SEVR by using applanation tonometry may provide a reliable tool for the assessment of coronary microcirculation in essential hypertensives with indications of myocardial ischaemia and normal coronary arteries.

Indexed as

AgedBlood Flow VelocityCoronary AngiographyCoronary CirculationCoronary StenosisCoronary VesselsEndocardiumFemaleFractional Flow Reserve, MyocardialHeart RateHumansHypertensionMaleMicrocirculationMiddle AgedMyocardial Ischemia

Identifiers

PMID21228823
OpenAlexW2071382764

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.