Evidence map›Paper›PMID 21228799›Full record

ArticleKidney international2011

Fueling the fire in acute kidney injury: endothelial cells collect their Toll.

Timothy A Sutton, Pierre C Dagher

Open access · bronzeAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Kidney international, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Timothy A SuttonDivision of Nephrology, Department of Medicine and the Indiana Center for Biological Microscopy, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA. tsutton2@iupui.edu
Pierre C Dagher
Indiana University School of Medicine

Funding

Pathophysiology of sepsis-induced renal injuryR01DK080067 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI DAGHER, PIERRE C · 2009 to 2013
$1.6M
Mechanisms of microvascular damage in acute kidney injuryR01DK077124 · NIDDK · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI SUTTON, TIMOTHY ALAN · 2007 to 2011
$1.3M
NIDDK NIH HHS R01 DK077124NIDDK NIH HHS R01 DK080067
6 · The paper itself

Abstract

Chen et al. demonstrate endothelial expression of Toll-like receptor 4 (TLR4) in the outer medulla of the kidney early in the course of ischemic acute kidney injury. Furthermore, they provide data that support the hypothesis that activation of endothelial TLR4 in the early extension phase of AKI by damage-associated molecular pattern molecules released from injured tubules results in endothelial activation. This activation can serve to amplify inflammation and tubular damage.

Indexed as

Acute Kidney InjuryAnimalsCell Adhesion MoleculesEndothelial CellsHMGB1 ProteinHumansIschemiaKidneyKidney Tubules, ProximalMiceReactive Oxygen SpeciesToll-Like Receptor 4Cell Adhesion MoleculesHMGB1 ProteinReactive Oxygen SpeciesToll-Like Receptor 4

Identifiers

PMID21228799
PMCPMC3086207
OpenAlexW1989953724

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.