ReviewJournal of innate immunity2011
Eosinophils: offenders or general bystanders in allergic airway disease and pulmonary immunity?
Review in Journal of innate immunity, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Role of IL-18-transformed CD274-expressing eosinophils in promoting airway obstruction in experimental asthma.Allergy · 2022Article
- Physiological responses to cisplatin using a mouse hypersensitivity model.Inhalation toxicology · 2020Article
- Effect of prenatal exposure to combined immunosuppressive agrochemicals in a mouse model of allergic airway inflammation.The Journal of veterinary medical science · 2019Article
- Asthma, Sinonasal Disease, and the Risk of Active Tuberculosis.The journal of allergy and clinical immunology. In practice · 2019Article
- Regulatory effects of IL-15 on allergen-induced airway obstruction.The Journal of allergy and clinical immunology · 2018Article
- Eosinophils and Mast Cells in Aspirin-Exacerbated Respiratory Disease.Immunology and allergy clinics of North America · 2016Review
- Spectrum of Eosinophilic End-Organ Manifestations.Immunology and allergy clinics of North America · 2015Review
- Anti-allergic properties of curine, a bisbenzylisoquinoline alkaloid.Molecules (Basel, Switzerland) · 2015Review
- Titanium dioxide exposure induces acute eosinophilic lung inflammation in rabbits.Industrial health · 2014Article
- Different anti-apoptotic effects of normal and asthmatic serum on normal eosinophil apoptosis depending on house dust mite-specific IgE.Molecular biology reports · 2013Article
- Prominent role of IFN-γ in patients with aspirin-exacerbated respiratory disease.The Journal of allergy and clinical immunology · 2013Article
- Two human host defense ribonucleases against mycobacteria, the eosinophil cationic protein (RNase 3) and RNase 7.Antimicrobial agents and chemotherapy · 2013Article
- Anti-IL-5 attenuates activation and surface density of β(2) -integrins on circulating eosinophils after segmental antigen challenge.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2013Article
- Eosinophilic inflammation in allergic asthma.Frontiers in pharmacology · 2013Article
- Eosinophil crystalloid granules: structure, function, and beyond.Journal of leukocyte biology · 2012Review
- Eosinophils and disease pathogenesis.Seminars in hematology · 2012Review
- Platelet activation, P-selectin, and eosinophil β1-integrin activation in asthma.American journal of respiratory and critical care medicine · 2012Article
- Cross-reactivity between halogenated platinum salts in an immediate-type respiratory hypersensitivity model.Inhalation toxicologyArticle
- Factors driving the aspirin exacerbated respiratory disease phenotype.American journal of rhinology & allergyReview
- Environmental exposures and airway inflammation in young thoroughbred horses.Journal of veterinary internal medicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Eosinophils have long been noted to be present in asthma and other forms of pulmonary inflammation, but whether they act as true offenders or merely as bystanders has been a point of uncertainty. However, in recent years, there has been increasing evidence suggesting that eosinophils are not passive cells in the respiratory system, acting only as markers of allergic inflammation. This review discusses key evidence from animal models and human clinical trials that support the importance of eosinophils as active and necessary, rather than passive and unnecessary, to the pathogenesis of allergic airway disease. Analyses that are supportive of important immunoregulatory roles of eosinophils in allergic pulmonary inflammation are also reviewed. Data indicating that eosinophils contribute to viral, bacterial, and mycobacterial defense and clearance are detailed. Continually increasing evidence has supported a new conception of eosinophils as being multifaceted immune cells with complex interactions with other immune cells and their local environment.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.