ArticleAmerican journal of epidemiology2011
Genetic variation in metabolic genes, occupational solvent exposure, and risk of non-hodgkin lymphoma.
Article in American journal of epidemiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 32 citations in OpenAlex.
- Trial
- Research Recommendations for Selected IARC-Classified Agents: Impact and Lessons Learned.Environmental health perspectives · 2023Review
- Association ofPharmacogenomics and personalized medicine · 2022Article
- Genetic variations in the drug metabolizing enzyme, CYP2E1, among various ethnic populations of Pakistan.PeerJ · 2020Article
- Acute and delayed toxicity from co-ingestion of methylene chloride and methanol.Toxicology communications · 2019Article
- Case-control investigation of occupational exposure to chlorinated solvents and non-Hodgkin's lymphoma.Occupational and environmental medicine · 2018Article
- Genetic polymorphism analysis of cytochrome P4502E1 (CYP2E1) in a Chinese Tibetan population.Medicine · 2017Article
- Experimental outgassing of toxic chemicals to simulate the characteristics of hazards tainting globally shipped products.PloS one · 2017Article
- Human health effects of dichloromethane: key findings and scientific issues.Environmental health perspectives · 2015Review
- Considerations for Using Genetic and Epigenetic Information in Occupational Health Risk Assessment and Standard Setting.Journal of occupational and environmental hygiene · 2015Article
- Polymorphisms in DNA repair genes, hair dye use, and the risk of non-Hodgkin lymphoma.Cancer causes & control : CCC · 2014Article
- Polymorphisms in xenobiotic metabolizing genes (EPHX1, NQO1 and PON1) in lymphoma susceptibility: a case control study.BMC cancer · 2013Article
- Occupational solvent exposure, genetic variation in immune genes, and the risk for non-Hodgkin lymphoma.European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) · 2013Article
- Occupational solvent exposure, genetic variation of DNA repair genes, and the risk of non-Hodgkin's lymphoma.European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) · 2012Article
- Current understanding of lifestyle and environmental factors and risk of non-hodgkin lymphoma: an epidemiological update.Journal of cancer epidemiology · 2012Article
- Insights from epidemiology into dichloromethane and cancer risk.International journal of environmental research and public health · 2011Review
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
Abstract
Using 1996-2000 data among Connecticut women, the authors evaluated whether genetic variation in 4 metabolic genes modifies organic solvent associations with non-Hodgkin lymphoma and 5 major histologic subtypes. P(interaction) values were determined from cross-product terms between dichotomous (ever/never) solvent variables and genotypes at examined loci in unconditional logistic regression models. The false discovery rate method was used to account for multiple comparisons. Overall associations between the chlorinated solvents dichloromethane (odds ratio (OR) = 1.69, 95% confidence interval (CI): 1.06, 2.69), carbon tetrachloride (OR = 2.33, 95% CI: 1.23, 4.40), and methyl chloride (OR = 1.44, 95% CI: 0.94, 2.20) and total non-Hodgkin lymphoma were increased among women TT for rs2070673 in the cytochrome P4502E1 gene, CYP2E1 (dichloromethane: OR = 4.42, 95% CI: 2.03, 9.62; P(interaction) < 0.01; carbon tetrachloride: OR = 5.08, 95% CI: 1.82, 14.15; P(interaction) = 0.04; and methyl chloride: OR = 2.37, 95% CI: 1.24, 4.51; P(interaction) = 0.03). In contrast, no effects of these solvents were observed among TA/AA women. Similar patterns were observed for diffuse large B-cell lymphoma and follicular lymphoma, as well as marginal zone lymphoma for dichloromethane. The weak, nonsignificant overall association between benzene and diffuse large B-cell lymphoma (OR = 1.29, 95% CI: 0.84, 1.98) was increased among women AA for rs2234922 in the microsomal epoxide hydrolase gene, EPHX1 (OR = 1.77, 95% CI: 1.06, 2.97; P(interaction) = 0.06). In contrast, no effect was observed among AG/GG women. Additional studies with larger sample size are needed to replicate these findings.
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