ArticleInvestigative ophthalmology & visual science2011
Evaluation of a transgenic mouse model of multiple sclerosis with noninvasive methods.
Article in Investigative ophthalmology & visual science, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 24 citations in OpenAlex.
- Review
- Nuclear prelamin a recognition factor and iron dysregulation in multiple sclerosis.Metabolic brain disease · 2020Article
- Retinal pathology in experimental optic neuritis is characterized by retrograde degeneration and gliosis.Acta neuropathologica communications · 2019Article
- The Role of Deimination in Regenerative Reprogramming of Neurons.Molecular neurobiology · 2019Article
- Optical Coherence Tomography and Magnetic Resonance Imaging in Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder.International journal of molecular sciences · 2016Review
- Calpain inhibition reduces structural and functional impairment of retinal ganglion cells in experimental optic neuritis.Journal of neurochemistry · 2016Article
- Robust mouse pattern electroretinograms derived simultaneously from each eye using a common snout electrode.Investigative ophthalmology & visual science · 2014Article
- Understanding disease processes in multiple sclerosis through magnetic resonance imaging studies in animal models.NeuroImage. Clinical · 2014Review
- Noninvasive assessments of optic nerve neurodegeneration in transgenic mice with isolated optic neuritis.Investigative ophthalmology & visual science · 2013Article
- Retrograde signaling in the optic nerve is necessary for electrical responsiveness of retinal ganglion cells.Investigative ophthalmology & visual science · 2013Article
- Deimination restores inner retinal visual function in murine demyelinating disease.The Journal of clinical investigation · 2013Article
- The bioelectric field of the pattern electroretinogram in the mouse.Investigative ophthalmology & visual science · 2012Article
- Retinal ganglion cell functional plasticity and optic neuropathy: a comprehensive model.Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society · 2012Review
- The role of deimination in ATP5b mRNA transport in a transgenic mouse model of multiple sclerosis.EMBO reports · 2012Article
- Spontaneous ocular and neurologic deficits in transgenic mouse models of multiple sclerosis and noninvasive investigative modalities: a review.Investigative ophthalmology & visual science · 2012Review
- Appropriate patient population for future visual system axon regeneration therapies.WIREs mechanisms of diseaseArticle
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
purposeTo evaluate the ND4 transgenic mouse model of multiple sclerosis using noninvasive methods.
methodsAssessment of neurologic/behavioral abnormalities was made using pattern electroretinogram (PERG), magnetic resonance imaging (MRI), optic coherence tomography (OCT), and end point histologic analysis.
resultsElectrophysiologic (PERG) recordings demonstrated functional deficits in vision commensurate with neurologic/behavioral abnormalities. In ND4 mice, the authors found PERG abnormalities preceded neurologic/gait abnormalities. MRI demonstrated subtle structural changes that progressed over time in correlation with behavioral abnormalities.
conclusionsThe ND4 mouse model has been evaluated using well-defined parameters of noninvasive methods (PERG, MRI, and OCT), enabling objective identification of functional and structural deficits and their correlation with neurologic/gait abnormality.
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Registered trials
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