ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2011
Low abundance of sweat duct Cl- channel CFTR in both healthy and cystic fibrosis athletes with exceptionally salty sweat during exercise.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 44 citations in OpenAlex.
- Characterization of the effects of the vasopressin V2 receptor on sweating, fluid balance, and performance during exercise.American journal of physiology. Regulatory, integrative and comparative physiology · 2014Trial
- Perspectives on enhancing human performance in the heat: Is the solution to simply "just add water"?Sports medicine and health science · 2025Review
- Beyond Trikafta: new models to assess tissue dependent rescue of N1303K-CFTR.Frontiers in pharmacology · 2025Article
- The Effects of Acute Deep Seawater Supplementation on Muscle Function after Triathlon.Journal of clinical medicine · 2024Article
- Exercise-Associated Hyponatremia in Marathon Runners.Journal of clinical medicine · 2022Review
- Physiological mechanisms determining eccrine sweat composition.European journal of applied physiology · 2020Review
- Dietary reference values for sodium.EFSA journal. European Food Safety Authority · 2019Article
- Exercise-Associated Hyponatremia in Endurance and Ultra-Endurance Performance-Aspects of Sex, Race Location, Ambient Temperature, Sports Discipline, and Length of Performance: A Narrative Review.Medicina (Kaunas, Lithuania) · 2019Review
- Physiology of sweat gland function: The roles of sweating and sweat composition in human health.Temperature (Austin, Tex.) · 2019Review
- Considering exercise-associated hyponatraemia as a continuum.BMJ case reports · 2018Article
- The effects of exercise and passive heating on the sweat glands ion reabsorption rates.Physiological reports · 2018Article
- Maximum rate of sweat ions reabsorption during exercise with regional differences, sex, and exercise training.European journal of applied physiology · 2017Article
- Interindividual variability in sweat electrolyte concentration in marathoners.Journal of the International Society of Sports Nutrition · 2016Article
- Three-dimensional co-culture of BM-MSCs and eccrine sweat gland cells in Matrigel promotes transdifferentiation of BM-MSCs.Journal of molecular histology · 2015Article
- CFTR-mediated Cl(-) transport in the acinar and duct cells of rabbit lacrimal gland.Current eye research · 2012Article
- High-sweat Na+ in cystic fibrosis and healthy individuals does not diminish thirst during exercise in the heat.American journal of physiology. Regulatory, integrative and comparative physiology · 2011Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
To understand potential mechanisms explaining interindividual variability observed in human sweat sodium concentration ([Na(+)]), we investigated the relationship among [Na(+)] of thermoregulatory sweat, plasma membrane expression of Na(+) and Cl(-) transport proteins in biopsied human eccrine sweat ducts, and basal levels of vasopressin (AVP) and aldosterone. Lower ductal luminal membrane expression of the Cl(-) channel cystic fibrosis transmembrane conductance regulator (CFTR) was observed in immunofluorescent staining of sweat glands from healthy young adults identified as exceptionally "salty sweaters" (SS) (n = 6, P < 0.05) and from patients with cystic fibrosis (CF) (n = 6, P < 0.005) compared with ducts from healthy young adults with "typical" sweat [Na(+)] (control, n = 6). Genetic testing of healthy subjects did not reveal any heterozygotes ("carriers") for any of the 39 most common disease-causing CFTR mutations in the United States. SS had higher baseline plasma [AVP] compared with control (P = 0.029). Immunostaining to investigate a potential relationship between higher plasma [AVP] (and sweat [Na(+)]) and ductal membrane aquaporin-5 revealed for all groups a relatively sparse and location-dependent ductal expression of the water channel with localization primarily to the secretory coil. Availability of CFTR for NaCl transport across the ductal membrane appears related to the significant physiological variability observed in sweat salt concentration in apparently healthy humans. At present, a heritable link between healthy salty sweaters and the most prevalent disease-causing CFTR mutations cannot be established.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.