ArticleThe Journal of biological chemistry2011
Glycoantigens induce human peripheral Tr1 cell differentiation with gut-homing specialization.
Article in The Journal of biological chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 39 citations in OpenAlex.
- Gut microbiota in regulatory T cell generation and function: mechanisms and health implications.Gut microbes · 2025Review
- Microbiota-dependent modulation of intestinal anti-inflammatory CD4Seminars in immunopathology · 2025Review
- Disruption of Genes Encoding Putative Zwitterionic Capsular Polysaccharides of Diverse Intestinal Bacteroides Reduces the Induction of Host Anti-Inflammatory Factors.Microbial ecology · 2023Article
- Intestinal Regulatory T Cells.Advances in experimental medicine and biology · 2021Article
- Treatment of Intestinal Inflammation With Epicutaneous Immunotherapy Requires TGF-β and IL-10 but Not Foxp3Frontiers in immunology · 2021Article
- Go With Your Gut: The Shaping of T-Cell Response by Gut Microbiota in Allergic Asthma.Frontiers in immunology · 2020Review
- Immunomodulatory Roles of Polysaccharide Capsules in the Intestine.Frontiers in immunology · 2020Review
- Immunological mechanisms underpinning faecal microbiota transplantation for the treatment of inflammatory bowel disease.Clinical and experimental immunology · 2020Review
- Bacteroides fragilis polysaccharide A induces IL-10 secreting B and T cells that prevent viral encephalitis.Nature communications · 2019Article
- CD45Rb-low effector T cells require IL-4 to induce IL-10 in FoxP3 Tregs and to protect mice from inflammation.PloS one · 2019Article
- Article
- Polysaccharide-experienced effector T cells induce IL-10 in FoxP3+ regulatory T cells to prevent pulmonary inflammation.Glycobiology · 2018Article
- Emerging glycobiology tools: A renaissance in accessibility.Cellular immunology · 2018Review
- Modulatory Influence of Segmented Filamentous Bacteria on Transcriptomic Response of Gnotobiotic Mice Exposed to TCDD.Frontiers in microbiology · 2017Article
- T cell-intrinsic TLR2 stimulation promotes IL-10 expression and suppressive activity by CD45RbHi T cells.PloS one · 2017Article
- Diverse Intestinal Bacteria Contain Putative Zwitterionic Capsular Polysaccharides with Anti-inflammatory Properties.Cell host & microbe · 2016Article
- Carbohydrates as T-cell antigens with implications in health and disease.Glycobiology · 2016Review
- Striking a Balance with Help from our Little Friends - How the Gut Microbiota Contributes to Immune Homeostasis.The Yale journal of biology and medicine · 2016Review
- A commensal symbiotic factor derived from Bacteroides fragilis promotes human CD39(+)Foxp3(+) T cells and Treg function.Gut microbes · 2015Article
- Bacterial capsular polysaccharide prevents the onset of asthma through T-cell activation.Glycobiology · 2015Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The carbohydrate antigen (glycoantigen) PSA from an intestinal commensal bacteria is able to down-regulate inflammatory bowel disease in model mice, suggesting that stimulation with PSA results in regulatory T cell (Treg) generation. However, mechanisms of how peripheral human T cells respond and home in response to commensal antigens are still not understood. Here, we demonstrate that a single exposure to PSA induces differentiation of human peripheral CD4(+) T cells into type-Tr1 Tregs. This is in contrast to mouse models where PSA induced the production of Foxp3(+) iTregs. The human PSA-induced Tr1 cells are profoundly anergic and exhibit nonspecific bystander suppression mediated by IL-10 secretion. Most surprisingly, glycoantigen exposure provoked expression of gut homing receptors on their surface. These findings reveal a mechanism for immune homeostasis in the gut whereby exposure to commensal glycoantigens provides the requisite information to responding T cells for proper tissue localization (gut) and function (anti-inflammatory/regulatory).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.