ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2011
Profound desensitization by ambient GABA limits activation of δ-containing GABAA receptors during spillover.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.
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Who cites it
73 citing papers in PubMed, 102 citations in OpenAlex.
- Article
- Decoding the structural and functional diversity of GABAFrontiers in pharmacology · 2025Review
- Loss-of-consciousness: sources of GABAergic input to the mesopontine tegmental anesthesia area.Frontiers in neuroscience · 2025Article
- The type of inhibition provided by thalamic interneurons alters the input selectivity of thalamocortical neurons.Current research in neurobiology · 2024Article
- Volume-transmitted GABA waves pace epileptiform rhythms in the hippocampal network.Current biology : CB · 2023Article
- Metabolic modulation of synaptic failure and thalamocortical hypersynchronization with preserved consciousness in Glut1 deficiency.Science translational medicine · 2022Article
- Neurotransmitter content heterogeneity within an interneuron class shapes inhibitory transmission at a central synapse.Frontiers in cellular neuroscience · 2022Article
- Mechanisms of GABAergic and cholinergic neurotransmission in auditory thalamus: Impact of aging.Hearing research · 2021Review
- Tonic GABAergic inhibition, via GABAThe European journal of neuroscience · 2021Article
- Reduced Activation of the Synaptic-Type GABAMolecular pharmacology · 2020Article
- The desensitization pathway of GABANature communications · 2020Article
- Silencing of spontaneous activity at α4β1/3δ GABABritish journal of pharmacology · 2020Article
- Regulation of GABAInternational journal of molecular sciences · 2020Review
- δ subunit-containing GABAThe Journal of physiology · 2020Article
- Mechanisms of GABAScientific reports · 2019Article
- The flavonoid, 2'-methoxy-6-methylflavone, affords neuroprotection following focal cerebral ischaemia.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019Article
- Direction of action of presynaptic GABAJournal of neurophysiology · 2019Article
- Chemogenetic Isolation Reveals Synaptic Contribution of δ GABAThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- GABA beyond the synapse: defining the subtype-specific pharmacodynamics of non-synaptic GABAThe Journal of physiology · 2018Article
- Probing GABANeuropharmacology · 2018Article
13 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
High-affinity extrasynaptic GABA(A) receptors (GABA(A)Rs) are a prominent feature of cerebellar granule neurons and thalamic relay neurons. In both cell types, the presence of synaptic glomeruli would be expected to promote activation of these GABA(A)Rs, contributing to phasic spillover-mediated currents and tonic inhibition. However, the precise role of different receptor subtypes in these two phenomena is unclear. To address this question, we made recordings from neurons in acute brain slices from mice, and from tsA201 cells expressing recombinant GABA(A)Rs. We found that δ subunit-containing GABA(A)Rs of both cerebellar granule neurons and thalamic relay neurons of the lateral geniculate nucleus contributed to tonic conductance caused by ambient GABA but not to spillover-mediated currents. In the presence of a low "ambient" GABA concentration, recombinant "extrasynaptic" δ subunit-containing GABA(A)Rs exhibited profound desensitization, rendering them insensitive to brief synaptic- or spillover-like GABA transients. Together, our results demonstrate that phasic spillover and tonic inhibition reflect the activation of distinct receptor populations.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.