ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2011
Phase advancement and nucleus-specific timing of thalamocortical activity during slow cortical oscillation.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Thalamic involvement defines distinct slow-wave subtypes in NREM sleep.Communications biology · 2026Article
- Thalamic involvement defines distinct slow-wave subtypes in NREM sleep.Research square · 2025Article
- Thalamic involvement defines distinct slow-wave subtypes in NREM sleep.bioRxiv : the preprint server for biology · 2025Article
- Corticothalamic modulation of somatosensory thalamic tactile processing.The Journal of physiology · 2025Article
- The transformative power of music: Insights into neuroplasticity, health, and disease.Brain, behavior, & immunity - health · 2024Review
- Behavioral, neural and ultrastructural alterations in a graded-dose 6-OHDA mouse model of early-stage Parkinson's disease.Scientific reports · 2023Article
- The human thalamus orchestrates neocortical oscillations during NREM sleep.Nature communications · 2022Article
- Distinct burst properties contribute to the functional diversity of thalamic nuclei.The Journal of comparative neurology · 2021Article
- mPFC spindle cycles organize sparse thalamic activation and recently active CA1 cells during non-REM sleep.eLife · 2020Article
- The (Un)Conscious Mouse as a Model for Human Brain Functions: Key Principles of Anesthesia and Their Impact on Translational Neuroimaging.Frontiers in systems neuroscience · 2020Review
- Thalamic Drive of Cortical Parvalbumin-Positive Interneurons during Down States in Anesthetized Mice.Current biology : CB · 2019Article
- Resonance with subthreshold oscillatory drive organizes activity and optimizes learning in neural networks.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
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- Neural Plasticity Is Involved in Physiological Sleep, Depressive Sleep Disturbances, and Antidepressant Treatments.Neural plasticity · 2017Review
- Corticothalamic Spike Transfer via the L5B-POm Pathway in vivo.Cerebral cortex (New York, N.Y. : 1991) · 2016Article
- Presynaptic Adenosine Receptor-Mediated Regulation of Diverse Thalamocortical Short-Term Plasticity in the Mouse Whisker Pathway.Frontiers in neural circuits · 2016Article
- Temporal Structure of Neuronal Activity among Cortical Neuron Subtypes during Slow Oscillations in Anesthetized Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- A subcortical inhibitory signal for behavioral arrest in the thalamus.Nature neuroscience · 2015Article
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4 authors.
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Abstract
The exact timing of cortical afferent activity is instrumental for the correct coding and retrieval of internal and external stimuli. Thalamocortical inputs represent the most significant subcortical pathway to the cortex, but the precise timing and temporal variability of thalamocortical activity is not known. To examine this question, we studied the phase of thalamic action potentials relative to cortical oscillations and established correlations among phase, the nuclear location of the thalamocortical neurons, and the frequency of cortical activity. The phase of thalamic action potentials depended on the exact frequency of the slow cortical oscillation both on long (minutes) and short (single wave) time scales. Faster waves were accompanied by phase advancement in both cases. Thalamocortical neurons located in different nuclei fired at significantly different phases of the slow waves but were active at a similar phase of spindle oscillations. Different thalamic nuclei displayed distinct burst patterns. Bursts with a higher number of action potentials displayed progressive phase advancement in a nucleus-specific manner. Thalamic neurons located along nuclear borders were characterized by mixed burst and phase properties. Our data demonstrate that the temporal relationship between cortical and thalamic activity is not fixed but displays dynamic changes during oscillatory activity. The timing depends on the precise location and exact activity of thalamocortical cells and the ongoing cortical network pattern. This variability of thalamic output and its coupling to cortical activity can enable thalamocortical neurons to actively participate in the coding and retrieval of cortical signals.
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