ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2011
Reelin is required for class-specific retinogeniculate targeting.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 60 citations in OpenAlex.
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- Mapping the Retina onto the Brain.Cold Spring Harbor perspectives in biology · 2024Review
- Teneurin-3 regulates the generation of non-image-forming visual circuitry and responsiveness to light in the suprachiasmatic nucleus.PLoS biology · 2023Article
- Semaphorin-6D and Plexin-A1 Act in a Non-Cell-Autonomous Manner to Position and Target Retinal Ganglion Cell Axons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Pattern of Driver-Like Input onto Neurons of the Mouse Ventral Lateral Geniculate Nucleus.eNeuro · 2023Article
- Sonic hedgehog-dependent recruitment of GABAergic interneurons into the developing visual thalamus.eLife · 2022Article
- Guidance landscapes unveiled by quantitative proteomics to control reinnervation in adult visual system.Nature communications · 2022Article
- Cross-hierarchical plasticity of corticofugal projections to dLGN after neonatal monocular enucleation.The Journal of comparative neurology · 2022Article
- Development of astrocyte morphology and function in mouse visual thalamus.The Journal of comparative neurology · 2022Article
- Diverse GABAergic neurons organize into subtype-specific sublaminae in the ventral lateral geniculate nucleus.Journal of neurochemistry · 2021Article
- A cell-ECM mechanism for connecting the ipsilateral eye to the brain.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Molecular mechanisms regulating synaptic specificity and retinal circuit formation.Wiley interdisciplinary reviews. Developmental biology · 2021Review
- Revisiting the role of Dcc in visual system development with a novel eye clearing method.eLife · 2020Article
- Retinal inputs signal astrocytes to recruit interneurons into visual thalamus.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Assembly and repair of eye-to-brain connections.Current opinion in neurobiology · 2018Review
- Distribution and development of molecularly distinct perineuronal nets in visual thalamus.Journal of neurochemistry · 2018Article
- Molecular guidance cues in the development of visual pathway.Protein & cell · 2018Review
- Retinal ganglion cell axon sorting at the optic chiasm requires dystroglycan.Developmental biology · 2018Article
- Neuronal integrity and complement control synaptic material clearance by microglia after CNS injury.The Journal of experimental medicine · 2018Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Development of visual system circuitry requires the formation of precise synaptic connections between neurons in the retina and brain. For example, axons from retinal ganglion cells (RGCs) form synapses onto neurons within subnuclei of the lateral geniculate nucleus (LGN) [i.e., the dorsal LGN (dLGN), ventral LGN (vLGN), and intergeniculate leaflet (IGL)]. Distinct classes of RGCs project to these subnuclei: the dLGN is innervated by image-forming RGCs, whereas the vLGN and IGL are innervated by non-image-forming RGCs. To explore potential mechanisms regulating class-specific LGN targeting, we sought to identify differentially expressed targeting molecules in these LGN subnuclei. One candidate targeting molecule enriched in the vLGN and IGL during retinogeniculate circuit formation was the extracellular matrix molecule reelin. Anterograde labeling of RGC axons in mutant mice lacking functional reelin (reln(rl/rl)) revealed reduced patterns of vLGN and IGL innervation and misrouted RGC axons in adjacent non-retino-recipient thalamic nuclei. Using genetic reporter mice, we further demonstrated that mistargeted axons were from non-image-forming, intrinsically photosensitive RGCs (ipRGCs). In contrast to mistargeted ipRGC axons, axons arising from image-forming RGCs and layer VI cortical neurons correctly targeted the dLGN in reln(rl/rl) mutants. Together, these data reveal that reelin is essential for the targeting of LGN subnuclei by functionally distinct classes of RGCs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.