ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2011
Location and function of the slow afterhyperpolarization channels in the basolateral amygdala.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 37 citations in OpenAlex.
- Instrumental learning enhances the intrinsic excitability of basal amygdala projection neurons.Learning & memory (Cold Spring Harbor, N.Y.) · 2026Article
- Basal forebrain innervation of the amygdala: an anatomical and computational exploration.Brain structure & function · 2025Article
- Mitochondrial CaCommunications biology · 2022Article
- Maturation of amygdala inputs regulate shifts in social and fear behaviors: A substrate for developmental effects of stress.Neuroscience and biobehavioral reviews · 2021Review
- Microcircuit mechanisms for the generation of sharp-wave ripples in the basolateral amygdala: A role for chandelier interneurons.Cell reports · 2021Article
- Noradrenaline Release from Locus Coeruleus Terminals in the Hippocampus Enhances Excitation-Spike Coupling in CA1 Pyramidal Neurons Via β-Adrenoceptors.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- The role of L-type calcium channels in neuronal excitability and aging.Neurobiology of learning and memory · 2020Review
- Modulation of intrinsic excitability as a function of learning within the fear conditioning circuit.Neurobiology of learning and memory · 2020Review
- NPYThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Distinct current modules shape cellular dynamics in model neurons.Neuroscience · 2016Article
- Synaptic competition in the lateral amygdala and the stimulus specificity of conditioned fear: a biophysical modeling study.Brain structure & function · 2016Article
- Article
- Postsynaptic adenosine A2A receptors modulate intrinsic excitability of pyramidal cells in the rat basolateral amygdala.The international journal of neuropsychopharmacology · 2015Article
- Distinct effects of repeated restraint stress on basolateral amygdala neuronal membrane properties in resilient adolescent and adult rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Article
- Learning to learn - intrinsic plasticity as a metaplasticity mechanism for memory formation.Neurobiology of learning and memory · 2013Review
- Assignment of model amygdala neurons to the fear memory trace depends on competitive synaptic interactions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Mechanisms contributing to the induction and storage of Pavlovian fear memories in the lateral amygdala.Learning & memory (Cold Spring Harbor, N.Y.) · 2013Article
- Developmental profile of localized spontaneous Ca(2+) release events in the dendrites of rat hippocampal pyramidal neurons.Cell calcium · 2012Article
- Pharmacological enhancement of calcium-activated potassium channel function reduces the effects of repeated stress on fear memory.Behavioural brain research · 2012Article
- Article
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4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The basolateral amygdala (BLA) assigns emotional significance to sensory stimuli. This association results in a change in the output (action potentials) of BLA projection neurons in response to the stimulus. Neuronal output is controlled by the intrinsic excitability of the neuron. A major determinant of intrinsic excitability in these neurons is the slow afterhyperpolarization (sAHP) that follows action potential (AP) trains and produces spike-frequency adaptation. The sAHP is mediated by a slow calcium-activated potassium current (sI(AHP)), but little is known about the channels that underlie this current. Here, using whole-cell patch-clamp recordings and high-speed calcium imaging from rat BLA projection neurons, we examined the location and function of these channels. We determined the location of the sI(AHP) by applying a hyperpolarizing voltage step during the sI(AHP) and measuring the time needed for the current to adapt to the new command potential, a function of its electrotonic distance from the somatic recording electrode. Channel location was also probed by focally uncaging calcium using a UV laser. Both methodologies indicated that, in BLA neurons, the sI(AHP) is primarily located in the dendritic tree. EPSPs recorded at the soma were smaller, decayed faster, and showed less summation during the sAHP. Adrenergic stimulation and buffering calcium reduced the sAHP and the attenuation of the EPSP during the sAHP. The sAHP also modulated the AP in the dendrite, reducing the calcium response evoked by a single AP. Thus, in addition to mediating spike-frequency adaptation, the sI(AHP) modulates communication between the soma and the dendrite.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.