Evidence map›Paper›PMID 21228145›Full record

ArticleClinical and vaccine immunology : CVI2011

Evaluation of serological diagnostic methods for the 2009 pandemic influenza A (H1N1) virus.

Jesse Papenburg, Mariana Baz, Marie-Ève Hamelin, Chantal Rhéaume, Julie Carbonneau, Manale Ouakki, Isabelle Rouleau, Gaston De Serres, Guy Boivin

Abstract readEvaluation Study
In one paragraph

Article in Clinical and vaccine immunology : CVI, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jesse PapenburgInfectious Disease Research Center of the CHUQ-CHUL and Laval University, Quebec City, Quebec, Canada.
Mariana Baz
Marie-Ève Hamelin
Chantal Rhéaume
Julie Carbonneau
Manale Ouakki
Isabelle Rouleau
Gaston De Serres
Guy Boivin

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Serology improves influenza diagnosis by capturing cases missed by reverse transcriptase PCR (RT-PCR). We prospectively evaluated microneutralization and hemagglutination inhibition assays for 2009 influenza A (H1N1) virus diagnosis among 24 RT-PCR-confirmed cases and 98 household contacts. Compared to hemagglutination inhibition, microneutralization demonstrated a higher level of concordance with RT-PCR (kappa = 0.69 versus kappa = 0.60) and greater sensitivity (83% versus 71%; P = 0.016).

Indexed as

AdolescentAdultChildClinical Laboratory TechniquesHemagglutination Inhibition TestsHumansInfluenza A Virus, H1N1 SubtypeInfluenza, HumanMiddle AgedNeutralization TestsProspective StudiesReverse Transcriptase Polymerase Chain ReactionRNA, ViralSensitivity and SpecificitySerologic TestsYoung AdultRNA, Viral

Identifiers

PMID21228145
PMCPMC3067392

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.