ArticleJournal of clinical microbiology2011
Human and swine hosts share vancomycin-resistant Enterococcus faecium CC17 and CC5 and Enterococcus faecalis CC2 clonal clusters harboring Tn1546 on indistinguishable plasmids.
Article in Journal of clinical microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed, 1 synthesis or guideline pooled it, 151 citations in OpenAlex.
- Vancomycin-resistant Enterococcus prevalence and its association along the food chain: a systematic review and meta-analysis.The Journal of antimicrobial chemotherapy · 2025Pooled it
- Narasin used as a feed additive in conventional rearing of broilers can co-select for vancomycin-resistant Enterococcus faecium through the NarAB ionophore resistance mechanisms.The Journal of antimicrobial chemotherapy · 2026Article
- Article
- One Health Approach of Enterococcal Population Structure and Antibacterial Resistance Along the Food Chain - Four PLADs, China, 2015-2022.China CDC weekly · 2024Article
- Emergence of lineage ST150 and linezolid resistance inFrontiers in microbiology · 2024Article
- Dissemination of Enterococcal Genetic Lineages: A One Health Perspective.Antibiotics (Basel, Switzerland) · 2023Review
- Phylogeny, Virulence, and Antimicrobial Resistance Gene Profiles ofAntibiotics (Basel, Switzerland) · 2023Article
- Virulence genes and antimicrobial resistance in Enterococcus strains isolated from dogs and cats in Northeast China.The Journal of veterinary medical science · 2023Article
- VanA-Enterococcus faecalis in Poland: hospital population clonal structure and vanA mobilome.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2022Article
- Antimicrobial Resistance, Biofilm Formation, and Virulence Genes inAntibiotics (Basel, Switzerland) · 2022Article
- Genomic Insights ofFrontiers in microbiology · 2022Article
- Role played by the environment in the emergence and spread of antimicrobial resistance (AMR) through the food chain.EFSA journal. European Food Safety Authority · 2021Article
- Mode and dynamics of vanA-type vancomycin resistance dissemination in Dutch hospitals.Genome medicine · 2021Article
- Enterococci, from Harmless Bacteria to a Pathogen.Microorganisms · 2020Review
- Phenotypic and Genotypic Traits of Vancomycin-Resistant Enterococci from Healthy Food-Producing Animals.Microorganisms · 2020Article
- Plasmids Shaped the Recent Emergence of the Major Nosocomial Pathogen Enterococcus faecium.mBio · 2020Article
- Food-to-Humans Bacterial Transmission.Microbiology spectrum · 2020Review
- Coexistence of the Oxazolidinone Resistance-Associated GenesFrontiers in public health · 2020Article
- Spatiotemporal dynamics of multidrug resistant bacteria on intensive care unit surfaces.Nature communications · 2019Article
- Phylogenetic Diversity and Antimicrobial Resistance of Campylobacter coli from Humans and Animals in Japan.Microbes and environments · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 7 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
VRE isolates from pigs (n = 29) and healthy persons (n = 12) recovered during wide surveillance studies performed in Portugal, Denmark, Spain, Switzerland, and the United States (1995 to 2008) were compared with outbreak/prevalent VRE clinical strains (n = 190; 23 countries; 1986 to 2009). Thirty clonally related Enterococcus faecium clonal complex 5 (CC5) isolates (17 sequence type 6 [ST6], 6 ST5, 5 ST185, 1 ST147, and 1 ST493) were obtained from feces of swine and healthy humans. This collection included isolates widespread among pigs of European Union (EU) countries since the mid-1990s. Each ST comprised isolates showing similar pulsed-field gel electrophoresis (PFGE) patterns (≤6 bands difference; >82% similarity). Some CC5 PFGE subtype strains from swine were indistinguishable from hospital vancomycin-resistant enterococci (VRE) causing infections. A truncated variant of Tn1546 (encoding resistance to vancomycin) and tcrB (coding for resistance to copper) were consistently located on 150- to 190-kb plasmids (rep(pLG1)). E. faecium CC17 (ST132) isolates from pig manure and two clinical samples showed identical PFGE profiles and contained a 60-kb mosaic plasmid (rep(Inc18) plus rep(pRUM)) carrying diverse Tn1546-IS1216 variants. The only Enterococcus faecalis isolate obtained from pigs (CC2-ST6) corresponded to a multidrug-resistant clone widely disseminated in hospitals in Italy, Portugal, and Spain, and both animal and human isolates harbored an indistinguishable 100-kb mosaic plasmid (rep(pRE25) plus rep(pCF10)) containing the whole Tn1546 backbone. The results indicate a current intra- and international spread of E. faecium and E. faecalis clones and their plasmids among swine and humans.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.