ReviewCurrent opinion in immunology2011
The invention of lymphocytes.
Review in Current opinion in immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 21 citations in OpenAlex.
- Origin of immunoglobulins and T cell receptors: A candidate gene for invasion by the RAG transposon.Science advances · 2025Article
- Immune checkpoint inhibitor-associated myocarditis: a historical and comprehensive review.American journal of physiology. Heart and circulatory physiology · 2025Review
- The Janus (dual) model of immunoglobulin isotype evolution: Conservation and plasticity are the defining paradigms.Immunological reviews · 2024Review
- Glutamine Metabolism Underlies the Functional Similarity of T Cells between Nile Tilapia and Tetrapod.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Immunonutrition: facilitating mucosal immune response in teleost intestine with amino acids through oxidant-antioxidant balance.Frontiers in immunology · 2023Review
- Inferring the "Primordial Immune Complex": Origins of MHC Class I and Antigen Receptors Revealed by Comparative Genomics.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- Article
- Re-evaluation of the immunological Big Bang.Current biology : CB · 2014Review
- Lamprey immunity is far from primitive.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- T cells home to the thymus and control infection.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Viral ancestors of antiviral systems.Viruses · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Lamprey and hagfish are surviving representatives of the most ancient vertebrates. They possess adaptive immune systems based on a vast, somatically diversified repertoire of lymphocyte-bound antigen receptors. Despite these similarities to antibody and T cell receptors (TCR) of later vertebrates, the variable lymphocyte receptors (VLR) are not related to the immunoglobulin (Ig)-superfamily of genes; and instead of V(D)J recombination VLR are somatically assembled by a gene conversion process. However, recent studies have revealed two lamprey lymphocyte subsets so closely resembling B cells and T cells that separate lymphocyte lineages must have already existed in the ancestral vertebrate, before Ig/TCR emergence. VLR and Ig/TCR arose independently, but the convergent evolution they display actually reflects their selection in cells with specialized functions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.