ArticleBMC medical genomics2011
Gastric cancers of Western European and African patients show different patterns of genomic instability.
Article in BMC medical genomics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Free intraperitoneal tumor cells and outcome in gastric cancer patients: a systematic review and meta-analysis.Oncotarget · 2015Pooled it
- Microsatellite status and its correlation with clinicopathological features in gastric carcinoma: insights from a retrospective study in Northern Pretoria.Pathology oncology research : POR · 2026Article
- A Review of Cancer Genetics and Genomics Studies in Africa.Frontiers in oncology · 2020Review
- Gastric Cancer Cell Lines Have DifferentCanadian journal of gastroenterology & hepatology · 2018Article
- Expression of Mismatch Repair Proteins in Early and Advanced Gastric Cancer in Poland.Medical science monitor : international medical journal of experimental and clinical research · 2016Article
- High-risk and low-risk gastric cancer areas in Italy and its association with microsatellite instability.Journal of cancer research and clinical oncology · 2016Article
- Molecular alterations in gastric cancer with special reference to the early-onset subtype.World journal of gastroenterology · 2016Review
- Helicobacter pylori infection and gastric carcinoma: Not all the strains and patients are alike.World journal of gastrointestinal oncology · 2016Review
- Pathogenetic mechanisms in gastric cancer.World journal of gastroenterology · 2014Review
- Perspectives on new biomarkers in gastric cancer: diagnostic and prognostic applications.World journal of gastroenterology · 2014Review
- Genetic amplification of PPME1 in gastric and lung cancer and its potential as a novel therapeutic target.Cancer biology & therapy · 2014Article
- Helicobacter pylori-induced alteration of epithelial cell signaling and polarity: a possible mechanism of gastric carcinoma etiology and disparity.Cytoskeleton (Hoboken, N.J.) · 2013Review
- KRAS and BRAF mutations are rare and related to DNA mismatch repair deficiency in gastric cancer from the East and the West: results from a large international multicentre study.British journal of cancer · 2013Article
- Incidence trends and mortality rates of gastric cancer in Israel.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2013Article
- Gastrointestinal adenocarcinomas of the esophagus, stomach, and colon exhibit distinct patterns of genome instability and oncogenesis.Cancer research · 2012Article
- Genetic aspects of gastric cancer instability.TheScientificWorldJournal · 2012Review
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInfection with H. pylori is important in the etiology of gastric cancer. Gastric cancer is infrequent in Africa, despite high frequencies of H. pylori infection, referred to as the African enigma. Variation in environmental and host factors influencing gastric cancer risk between different populations have been reported but little is known about the biological differences between gastric cancers from different geographic locations. We aim to study genomic instability patterns of gastric cancers obtained from patients from United Kingdom (UK) and South Africa (SA), in an attempt to support the African enigma hypothesis at the biological level.
methodsDNA was isolated from 67 gastric adenocarcinomas, 33 UK patients, 9 Caucasian SA patients and 25 native SA patients. Microsatellite instability and chromosomal instability were analyzed by PCR and microarray comparative genomic hybridization, respectively. Data was analyzed by supervised univariate and multivariate analyses as well as unsupervised hierarchical cluster analysis.
resultsTumors from Caucasian and native SA patients showed significantly more microsatellite instable tumors (p < 0.05). For the microsatellite stable tumors, geographical origin of the patients correlated with cluster membership, derived from unsupervised hierarchical cluster analysis (p = 0.001). Several chromosomal alterations showed significantly different frequencies in tumors from UK patients and native SA patients, but not between UK and Caucasian SA patients and between native and Caucasian SA patients.
conclusionsGastric cancers from SA and UK patients show differences in genetic instability patterns, indicating possible different biological mechanisms in patients from different geographical origin. This is of future clinical relevance for stratification of gastric cancer therapy.
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