ArticleBMC medical genomics2011
Co-regulatory expression quantitative trait loci mapping: method and application to endometrial cancer.
Article in BMC medical genomics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 3 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins.Nature communications · 2014Pooled it
- Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci.American journal of human genetics · 2014Pooled it
- Loci influencing blood pressure identified using a cardiovascular gene-centric array.Human molecular genetics · 2013Pooled it
- Identification of prognostic biomarkers and development of a prediction model for prostate cancer.Frontiers in immunology · 2025Article
- Alternatively Constructed Estrogen Receptor Alpha-Driven Super-Enhancers Result in Similar Gene Expression in Breast and Endometrial Cell Lines.International journal of molecular sciences · 2020Article
- IdentifyingGenome research · 2017Article
- miR-145 targets theAmerican journal of cancer research · 2017Article
- Novel distal eQTL analysis demonstrates effect of population genetic architecture on detecting and interpreting associations.Genetics · 2014Article
- Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.Nature · 2014Article
- Effects of long-term averaging of quantitative blood pressure traits on the detection of genetic associations.American journal of human genetics · 2014Article
- Imputation of exome sequence variants into population- based samples and blood-cell-trait-associated loci in African Americans: NHLBI GO Exome Sequencing Project.American journal of human genetics · 2012Article
- Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases.PLoS genetics · 2012Article
- Comparative genomics of esophageal adenocarcinoma and squamous cell carcinoma.The Annals of thoracic surgery · 2012Article
- Dyslexia risk variant rs600753 is linked with dyslexia-specific differential allelic expression of DYX1C1.Genetics and molecular biologyArticle
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Authors and funding
2 authors.
Funding
Abstract
backgroundExpression quantitative trait loci (eQTL) studies have helped identify the genetic determinants of gene expression. Understanding the potential interacting mechanisms underlying such findings, however, is challenging.
methodsWe describe a method to identify the trans-acting drivers of multiple gene co-expression, which reflects the action of regulatory molecules. This method-termed co-regulatory expression quantitative trait locus (creQTL) mapping-allows for evaluation of a more focused set of phenotypes within a clear biological context than conventional eQTL mapping.
resultsApplying this method to a study of endometrial cancer revealed regulatory mechanisms supported by the literature: a creQTL between a locus upstream of STARD13/DLC2 and a group of seven IFNβ-induced genes. This suggests that the Rho-GTPase encoded by STARD13 regulates IFNβ-induced genes and the DNA damage response.
conclusionsBecause of the importance of IFNβ in cancer, our results suggest that creQTL may provide a finer picture of gene regulation and may reveal additional molecular targets for intervention. An open source R implementation of the method is available at http://sites.google.com/site/kenkompass/.
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