Evidence map›Paper›PMID 21226886›Full record

Trial reportAddiction (Abingdon, England)2011

Employment-based abstinence reinforcement as a maintenance intervention for the treatment of cocaine dependence: post-intervention outcomes.

Anthony DeFulio, Kenneth Silverman

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Addiction (Abingdon, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 2 pooled it
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.

  1. Psychosocial interventions for stimulant use disorder.The Cochrane database of systematic reviews · 2024
    Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Trial
  6. Trial
  7. Trial
  8. Trial
  9. Trial
  10. Review
  11. Article
  12. Review
  13. Article
  14. Contingency Management for Drug Use Disorders: Meta-Analysis and Application of Tolin's Criteria.Clinical psychology : a publication of the Division of Clinical Psychology of the American Psychological Association · 2024
    Article
  15. Review
  16. Psychometric evaluation of the Reward Probability Index in emerging adult drinkers.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2021
    Article
  17. Article
  18. Article
  19. Psychosocial interventions for psychostimulant misuse.The Cochrane database of systematic reviews · 2016
    Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Anthony DeFulioJohns Hopkins University School of Medicine, Baltimore, MD, USA. adefuli1@jhmi.edu
Kenneth Silverman
Johns Hopkins Medicine · US

Funding

HUMAN BEHAVIORAL PHARMACOLOGY OF SUBSTANCE ABUSET32DA007209 · NIDA · JOHNS HOPKINS UNIVERSITY · PI Eric C. Strain, Elise M Weerts · 1985 to 2026
$12.9M
A REINFORCEMENT-BASED THERATPEUTIC WORKPLACER01DA013107 · NIDA · JOHNS HOPKINS UNIVERSITY · PI SILVERMAN, KENNETH · 1999 to 2006
$3.2M
NIDA NIH HHS R01 DA013107NIDA NIH HHS R01DA13107NIDA NIH HHS T32 DA007209NIDA NIH HHS T32DA07209
6 · The paper itself

Abstract

aimsDue to the chronicity of cocaine dependence, practical and effective maintenance interventions are needed to sustain long-term abstinence. We sought to assess the effects of long-term employment-based reinforcement of cocaine abstinence after discontinuation of the intervention.

designParticipants who initiated sustained opiate and cocaine abstinence during a 6-month abstinence reinforcement and training program worked as data entry operators and were randomly assigned to a group that could work independently of drug use (control, n = 24), or an abstinence-contingent employment (n = 27) group that was required to provide cocaine- and opiate-negative urine samples to work and maintain maximum rate of pay.

settingA non-profit data entry business.

participantsUnemployed welfare recipients who persistently used cocaine while in methadone treatment. MEASUREMENTS: Urine samples and self-reports were collected every 6 months for 30 months.

findingsDuring the employment year, abstinence-contingent employment participants provided significantly more cocaine-negative samples than controls (82.7% and 54.2%; P = 0.01, OR = 4.61). During the follow-up year, the groups had similar rates of cocaine-negative samples (44.2% and 50.0%; P = 0.93) and human immunodeficiency virus risk behaviors. Participants' social, employment, economic and legal conditions were similar in the two groups across all phases of the study.

conclusionsEmployment-based reinforcement effectively maintains long-term cocaine abstinence, but many patients relapse to use when the abstinence contingency is discontinued, even after a year of abstinence-contingent employment. Relapse could be prevented in many patients by leaving employment-based abstinence reinforcement in place indefinitely, which could be facilitated by integrating it into typical workplaces.

Indexed as

Patient ComplianceReinforcement, PsychologyAdultBaltimoreBehavior TherapyBreath TestsCocaine-Related DisordersEmploymentFemaleHumansMaleMethadoneNarcoticsOpiate Substitution TreatmentOutcome Assessment, Health CareRisk-TakingMethadoneNarcotics

Identifiers

PMID21226886
PMCPMC3074032
OpenAlexW2141331535

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.