ArticleNeurogastroenterology and motility2011
Postnatal development of the serotonin signaling system in the mucosa of the guinea pig ileum.
Article in Neurogastroenterology and motility, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 10 citations in OpenAlex.
- Localization of the Serotonin Transporter in the Dog Intestine and Comparison to the Rat and Human Intestines.Frontiers in veterinary science · 2021Article
- Beneficial Effect of Mildly Pasteurized Whey Protein on Intestinal Integrity and Innate Defense in Preterm and Near-Term Piglets.Nutrients · 2020Article
- Role of serotonin in the intestinal mucosal epithelium barrier in weaning mice undergoing stress-induced diarrhea.Journal of molecular histology · 2018Article
- TPH gene polymorphisms are associated with disease perception and quality of life in women with irritable bowel syndrome.Biological research for nursing · 2014Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundSerotonin is an important neurohumoral molecule in the gut but its signaling system is not fully developed in the neonatal gastrointestinal (GI) tract. This study aimed to evaluate the postnatal maturation of serotonin signaling in the small intestine.
methodsIn vitro amperometry for real-time measurement of serotonin at the mucosal surface, immunoblot, immunohistochemistry and high-performance liquid chromatography (HPLC) were used to examine serotonin handling in ileal segments from guinea pigs of different ages. KEY
resultsExtracellular serotonin levels significantly declined over the first three postnatal weeks, after which the levels increased and reached their maximum at 9 weeks postnatally. Serotonin levels were insensitive to the inhibition of the serotonin transporter (SERT) until the animals reached 3 weeks old. Measurement of serotonin and its metabolite 5-hydroxyindole acetic acid (5-HIAA) in the mucosa revealed that the serotonin turnover was significantly lower in neonates. Immunoblot and immunohistochemistry showed that SERT expression was extremely low in the neonatal period. Serotonin staining in cross-section showed that enterochromaffin (EC) cells were preferentially localized in the crypt region in neonates and the number of EC cells was significantly higher in 9-week-old animals. CONCLUSIONS & INFERENCES: SERT expression is low in the neonatal intestine and serotonin signaling matures postnatally. Extracellular serotonin levels decrease during the first three neonatal weeks as SERT expression increases. Extracellular serotonin levels increase after 3 weeks (weaning) possibly due to an increase in EC cell numbers. Postnatal maturation of serotonin signaling coincides with dietary changes in the developing guinea pig.
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