Evidence map›Paper›PMID 21226789›Full record

Trial reportBritish journal of health psychology2011

Personality and medication non-adherence among older adults enrolled in a six-year trial.

Anthony Jerant, Benjamin Chapman, Paul Duberstein, John Robbins, Peter Franks

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in British journal of health psychology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 1 pooled it
7.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 1 synthesis or guideline pooled it, 85 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Anthony JerantCenter for Healthcare Policy and Research, Department of Family and Community Medicine, University of California Davis School of Medicine, Sacramento, California, USA. aflerant@ucdavis.edu
Benjamin Chapman
Paul Duberstein
John Robbins
Peter Franks
Center For Policy Research · USUniversity of Rochester · USUniversity of California, Davis · US

Funding

TREATMENT OF DEPRESSION IN ALZHEIMER'S DISEASEP50AG005133 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SWEET, ROBERT A · 1985 to 2019
$43.0M
GINKGO BILOBA PREVENTION TRIAL IN OLDER INDIVIDUALSU01AT000162 · NCCIH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LOPEZ, OSCAR L. · 1999 to 2009
$34.7M
Postdoctoral Training in Geriatric Psychiatry ResearchT32MH073452 · NIMH · UNIVERSITY OF ROCHESTER · PI LYNESS, JEFFREY M · 2005 to 2009
$798k
LLD Course & Treatment Decisions: Psychosocial InfluencesK24MH072712 · NIMH · UNIVERSITY OF ROCHESTER · PI DUBERSTEIN, PAUL R · 2006 to 2010
$722k
NCCIH NIH HHS U01 AT000162NIAID NIH HHS U01AI000162NIA NIH HHS P50 AG005133NIA NIH HHS P50AG05133NIMH NIH HHS K24 MH072712NIMH NIH HHS K24MH072712NIMH NIH HHS T32 MH073452NIMH NIH HHS T32MH073452
6 · The paper itself

Abstract

objectivesPersonality factors parsimoniously capture the variation in dispositional characteristics that affect behaviours, but their value in predicting medication non-adherence is unclear. We investigated the relationship between five-factor model personality factors (Conscientiousness, Neuroticism, Agreeableness, Extraversion, and Openness) and medication non-adherence among older participants during a six-year randomized placebo-controlled trial (RCT).

designObservational cohort data from 771 subjects aged ≥ 72 years enrolled in the Ginkgo Evaluation of Memory study, a RCT of Ginkgo biloba for prevention of dementia.

methodsRandom effects logistic regression analyses examined effects of NEO Five-Factor Inventory scores on medication non-adherence, determined via pill counts every 6 months (median follow-up 6.1 years) and defined as taking <80% of prescribed pills. Analyses adjusted for covariates linked with non-adherence in prior studies.

resultsEach 5 year increment in participant age was associated with a 6.7% greater probability of non-adherence (95% confidence interval, CI [2.4, 11.0]). Neuroticism was the only personality factor associated with non-adherence: a 1 SD increase was associated with a 3.8% increase in the probability of non-adherence (95% CI [0.4, 7.2]). Lower cognitive function was also associated with non-adherence: a 1 SD decrease in mental status exam score was associated with a 3.0% increase in the probability of non-adherence (95% CI [0.2, 5.9]).

conclusionsNeuroticism was associated with medication non-adherence over 6 years of follow-up in a large sample of older RCT participants. Personality measurement in clinical and research settings might help to identify and guide interventions for older adults at risk for medication non-adherence.

Indexed as

Drug MonitoringPersonalityAgedAged, 80 and overAge FactorsAgingCohort StudiesDementiaFemaleFollow-Up StudiesGeriatric AssessmentGinkgo bilobaHumansMaleMedication AdherenceMemory

Identifiers

PMID21226789
PMCPMC3126620
OpenAlexW1927249329

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.