Evidence map›Paper›PMID 21226580›Full record

ReviewThe New England journal of medicine2011

Iron-chelating therapy for transfusional iron overload.

Gary M Brittenham

Registry-linked trialAbstract readReview
In one paragraph

Review in The New England journal of medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01892644 (Deferasirox Versus Venesection in Patients With Hemochromatosis and for Treatment of Transfusional Siderosis in Myelodysplastic Syndrome), which is not on this map. Cited by 147 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
147citing papers in PubMed, 1 pooled it
16.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01892644 phase2withdrawnnot on this mapstarted 2013, after this paper: background citation

Deferasirox Versus Venesection in Patients With Hemochromatosis and for Treatment of Transfusional Siderosis in Myelodysplastic Syndrome: Diagnostics and New Biomarkers.

TypeinterventionalSponsorHaukeland University HospitalRan2013 to 2017Enrolled0ConditionsHemochromatosis, Myelodysplastic SyndromesArmsDeferasirox, Venesection
3 · Its place in the literature

Who cites it

147 citing papers in PubMed, 1 synthesis or guideline pooled it, 358 citations in OpenAlex.

  1. Guideline
  2. Trial
  3. Trial
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  9. Review
  10. Observational
  11. Review
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  18. Article
  19. Cardiac MR Fingerprinting: Overview, Technical Developments, and Applications.Journal of magnetic resonance imaging : JMRI · 2024
    Review
  20. Article

87 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author at 1 institution in 2 countries.

Gary M BrittenhamDivision of Pediatric Hematology, Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York, NY, USA. gmb31@columbia.edu
Columbia College · CA

Funding

Iron Chelators Predicated on DesferrithiocinR37DK049108 · NIDDK · UNIVERSITY OF FLORIDA · PI BERGERON, RAYMOND JOSEPH · 2005 to 2014
$6.0M
ORAL IRON CHELATORS PREDICATED ON DESFERRITHIOCINR01DK049108 · NIDDK · UNIVERSITY OF FLORIDA · PI BERGERON, RAYMOND JOSEPH · 1995 to 2004
$3.2M
Magnetic Resonance Measurement of Heart and Liver IronR01DK066251 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BRITTENHAM, GARY M · 2003 to 2006
$1.6M
High-Tc susceptometer to monitor transfusional iron overload (NSR device)R01FD003702 · FDA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BRITTENHAM, GARY M · 2010 to 2014
$1.6M
FDA HHS R01 FD003702NIDDK NIH HHS R01 DK049108NIDDK NIH HHS R01 DK066251NIDDK NIH HHS R37 DK049108
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Chelation TherapyAdolescentAnemia, Sickle CellBenzoatesDeferasiroxDeferoxamineErythrocyte TransfusionHumansIronIron Chelating AgentsIron OverloadMalePractice Guidelines as TopicTriazolesBenzoatesDeferasiroxDeferoxamineIronIron Chelating AgentsTriazoles

Identifiers

PMID21226580
PMCPMC3078566
OpenAlexW2065268020

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.