ArticleMolecular biology reports2011
Single nucleotide polymorphism of CACNA2D1 gene and its association with milk somatic cell score in cattle.
Article in Molecular biology reports, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 28 citations in OpenAlex.
- Candidate genes for mastitis resistance in dairy cattle: a data integration approach.Journal of animal science and biotechnology · 2023Article
- Genetic polymorphisms in immune- and inflammation-associated genes and their association with bovine mastitis resistance/susceptibility.Frontiers in immunology · 2023Review
- Assessing Population Structure and Signatures of Selection in Wanbei Pigs Using Whole Genome Resequencing Data.Animals : an open access journal from MDPI · 2022Article
- Inputs for optimizing selection platform for milk production traits of dairy Sahiwal cattle.PloS one · 2022Article
- Bovine mastitis prevention and control in the post-antibiotic era.Tropical animal health and production · 2021Review
- Genetic Parameters and Genome-Wide Association Studies of Eight Longevity Traits Representing Either Full or Partial Lifespan in Chinese Holsteins.Frontiers in genetics · 2021Article
- Signatures of Selection in Composite Vrindavani Cattle of India.Frontiers in genetics · 2020Article
- Two single nucleotide polymorphisms sites inJournal of biological research (Thessalonike, Greece) · 2017Article
- Molecular biological tools applied for identification of mastitis causing pathogens.International journal of veterinary science and medicine · 2017Review
- Molecular markers for resistance against infectious diseases of economic importance.Veterinary world · 2017Review
- Effects of DGAT1 gene on meat and carcass fatness quality in Chinese commercial cattle.Molecular biology reports · 2013Article
- SNPs identification and its correlation analysis with milk somatic cell score in bovine MBL1 gene.Molecular biology reports · 2013Article
- BRCA1: a new candidate gene for bovine mastitis and its association analysis between single nucleotide polymorphisms and milk somatic cell score.Molecular biology reports · 2012Article
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Authors and funding
12 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective of the present study was to identify polymorphisms of the CACNA2D1 gene, and to analyze associations between these polymorphisms and mastitis in several cattle breeds. Through PCR-RFLP methods and DNA sequencing, an allelic variant corresponding to the A→G mutations and Aspartic (Asp) to Glycine (Gly) amino acid replacement at positions 526745 in the exon 25 of bovine CACNA2D1 gene could be detected. Two alleles, A and G, and three genotypes, AA, AG and GG were defined. Genetic character in the studied populations indicated that the A526745G loci of CACNA2D1 gene was moderate polymorphism and fitted with Hardy-Weinberg equilibrium (P > 0.05). The effects of CACNA2D1 polymorphisms on somatic cell score (SCS) were analyzed and significant association was found between A526745G and SCS. The mean of genotype GG was significantly lower than those of genotype AG and AA (P = 0.0469). Information provided in this research could be useful in further studies to determine the role of CACNA2D1 gene in the mastitis resistance.
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