Evidence map›Paper›PMID 21225409›Full record

ArticleCurrent topics in behavioral neurosciences2011

Mouse models of autism: testing hypotheses about molecular mechanisms.

Florence I Roullet, Jacqueline N Crawley

Abstract read
In one paragraph

Article in Current topics in behavioral neurosciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed.

  1. Article
  2. Prenatal Interferon-Alpha Exposure Induces Autism-Like Neurobehavioral and Neurochemical Alterations in Male Offspring.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Autism-like symptoms by exposure to air pollution and valproic acid-induced in male rats.Environmental science and pollution research international · 2022
    Article
  10. A Critical Period for Development of Cerebellar-Mediated Autism-Relevant Social Behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
  11. Effects of PMParticle and fibre toxicology · 2020
    Article
  12. Review
  13. Review
  14. Article
  15. Insulin-Like Growth Factor II Targets the mTOR Pathway to Reverse Autism-Like Phenotypes in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018
    Article
  16. Article
  17. Oxidative Stress, Maternal Diabetes, and Autism Spectrum Disorders.Oxidative medicine and cellular longevity · 2018
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Florence I RoulletLaboratory of Behavioral Neuroscience, Intramural Research Program, National Institute of Mental Health, Building 35 Room 1C-903/909, Mail Code 3730, Bethesda, MD, 20892-3730, USA, firoullet@gmail.com.
Jacqueline N Crawley

Funding

Animal Models Of Neuropsychiatric DisordersZIAMH002179 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI CRAWLEY, JACQUELINE N · 2009 to 2012
$6.4M
Intramural NIH HHS ZIA MH002179
6 · The paper itself

Abstract

Autism is a neurodevelopmental disorder that is currently diagnosed by the presence of three behavioral criteria (1) qualitative impairments in reciprocal social interactions, (2) deficits in communication, including delayed language and noninteractive conversation, and (3) motor stereotypies, repetitive behaviors, insistence on sameness, and restricted interests. This chapter describes analogous behavioral assays that have been developed for mice, including tests for social approach, reciprocal social interactions, olfactory communication, ultrasonic vocalizations, repetitive and perseverative behaviors, and motor stereotypies. Examples of assay applications to genetic mouse models of autism are provided. Robust endophenotypes that are highly relevant to the core symptoms of autism are enabling the search for the genetic and environmental causes of autism, and the discovery of effective treatments.

Indexed as

Autistic DisorderDisease Models, AnimalAnimalsInterpersonal RelationsMiceSocial Behavior

Identifiers

PMID21225409
PMCPMC3396120

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.