ArticleEuropean journal of human genetics : EJHG2011
Dissection of the MYCN locus in Feingold syndrome and isolated oesophageal atresia.
Article in European journal of human genetics : EJHG, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 29 citations in OpenAlex.
- Article
- Article
- Amniotic fluid stem cell extracellular vesicles as a novel fetal therapy for pulmonary hypoplasia: a review on mechanisms and translational potential.Stem cells translational medicine · 2025Review
- Article
- A new variant of MYCN gene as a cause of Feingold syndrome.Clinical case reports · 2022Article
- Genome sequencing identifies three molecular diagnoses including a mosaic variant in theCold Spring Harbor molecular case studies · 2021Article
- Developmental basis of trachea-esophageal birth defects.Developmental biology · 2021Review
- Occurrence of Esophageal Atresia With Tracheoesophageal Fistula in Siblings From Three-Generation Family Affected by Variable ExpressivityFrontiers in pediatrics · 2021Article
- A Novel MYCN Variant Associated with Intellectual Disability Regulates Neuronal Development.Neuroscience bulletin · 2018Article
- A Drosophila Model of Intellectual Disability Caused by Mutations in the Histone Demethylase KDM5.Cell reports · 2018Article
- The MYCN Protein in Health and Disease.Genes · 2017Review
- Copy number variations in 375 patients with oesophageal atresia and/or tracheoesophageal fistula.European journal of human genetics : EJHG · 2016Article
- Deletions and de novo mutations of SOX11 are associated with a neurodevelopmental disorder with features of Coffin-Siris syndrome.Journal of medical genetics · 2016Article
- The MRN complex is transcriptionally regulated by MYCN during neural cell proliferation to control replication stress.Cell death and differentiation · 2016Article
- MiR-449a Affects Epithelial Proliferation during the Pseudoglandular and Canalicular Phases of Avian and Mammal Lung Development.PloS one · 2016Article
- Neurobehavioral Alterations in a Genetic Murine Model of Feingold Syndrome 2.Behavior genetics · 2015Article
- The multifactorial origin of respiratory morbidity in patients surviving neonatal repair of esophageal atresia.Frontiers in pediatrics · 2014Review
- Control of vertebrate development by MYC.Cold Spring Harbor perspectives in medicine · 2013Review
- Germline deletion of the miR-17∼92 cluster causes skeletal and growth defects in humans.Nature genetics · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors at 13 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Feingold syndrome (FS) is a syndromic microcephaly entity for which MYCN is the major disease-causing gene. We studied the expression pattern of MYCN at different stages of human embryonic development and collected a series of 17 FS and 12 isolated oesophageal atresia (IOA) cases. An MYCN gene deletion/mutation was identified in 47% of FS cases exclusively. We hypothesized that mutations or deletions of highly conserved non-coding elements (HCNEs) at the MYCN locus could lead to its misregulation and thereby to FS and/or IOA. We subsequently sequenced five HCNEs at the MYCN locus and designed a high-density tiling path comparative genomic hybridization array of 3.3 Mb at the MYCN locus. We found no mutations or deletions in this region, supporting the hypothesis of genetic heterogeneity in FS.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.